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Bartke, T. ; Groth, A.*

A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks.

Mol. Cell. Oncol. 6:1605820 (2019)

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Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.

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Publication type Article: Journal article

Document type Other: Opinion

Corresponding Author

Keywords 53bp1 ; Bard1 ; Brca1 ; Dna Double Strand Break Repair ; Homologous Recombination

e-ISSN 2372-3556

Journal Molecular & Cellular Oncology

Quellenangaben Volume: 6, Issue: 4, Article Number: 1605820

Publisher Taylor & Francis

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Functional Epigenetics (IFE)