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Liu, C.T.* ; Merino, J.* ; Rybin, D.* ; DiCorpo, D.* ; Benke, K.S.* ; Bragg-Gresham, J.L.* ; Canouil, M.* ; Corre, T.* ; Grallert, H. ; Isaacs, A.* ; Kutalik, Z.* ; Lahti, J.* ; Marullo, L.* ; Marzi, C. ; Rasmussen-Torvik, L.J.* ; Rocheleau, G.* ; Rueedi, R.* ; Scapoli, C.* ; Verweij, N.* ; Vogelzangs, N.* ; Willems, S.M.* ; Yengo, L.* ; Bakker, S.J.L.* ; Beilby, J.* ; Hui, J.* ; Kajantie, E.* ; Müller-Nurasyid, M. ; Rathmann, W.* ; Balkau, B.* ; Bergmann, S.* ; Eriksson, J.G.* ; Florez, J.C.* ; Froguel, P.* ; Harris, T.* ; Hung, J.* ; James, A.L.* ; Kavousi, M.* ; Miljkovic, I.* ; Musk, A.W.* ; Palmer, L.J.* ; Peters, A. ; Roussel, R.* ; van der Harst, P.* ; van Duijn, C.M.* ; Vollenweider, P.* ; Barroso, I.* ; Prokopenko, I.* ; Dupuis, J.* ; Meigs, J.B.* ; Bouatia-Naji, N.*

Genome-wide association study of change in fasting glucose over time in 13,807 non-diabetic European Ancestry Individuals.

Sci. Rep. 9:9439 (2019)

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Type 2 diabetes (T2D) affects the health of millions of people worldwide. The identification of genetic determinants associated with changes in glycemia over time might illuminate biological features that precede the development of T2D. Here we conducted a genome-wide association study of longitudinal fasting glucose changes in up to 13,807 non-diabetic individuals of European descent from nine cohorts. Fasting glucose change over time was defined as the slope of the line defined by multiple fasting glucose measurements obtained over up to 14 years of observation. We tested for associations of genetic variants with inverse-normal transformed fasting glucose change over time adjusting for age at baseline, sex, and principal components of genetic variation. We found no genome-wide significant association (P < 5 x 10(-8)) with fasting glucose change over time. Seven loci previously associated with T2D, fasting glucose or HbA1c were nominally (P < 0.05) associated with fasting glucose change over time. Limited power influences unambiguous interpretation, but these data suggest that genetic effects on fasting glucose change over time are likely to be small. A public version of the data provides a genomic resource to combine with future studies to evaluate shared genetic links with T2D and other metabolic risk traits.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Life-style Intervention; Genetic Architecture; Weight-loss; Type-2; Prevention; Variants; Risk; Loci; Population; Prediction

ISSN (print) / ISBN 2045-2322

e-ISSN 2045-2322

Journal Scientific Reports

Quellenangaben Volume: 9, Issue: 1, Article Number: 9439

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)
Institute of Genetic Epidemiology (IGE)