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Catching lipid droplet contacts by proteomics.
Contact 2, DOI: 10.1177/2515256419859186 (2019)
Lipid droplets (LDs), important organelles for energy storage and involved in the development of metabolic disorders, are extremely dynamic and interact with many other cellular compartments to orchestrate lipid metabolism. Little is known about how these organelle contacts are changed according to cellular needs and functions under different metabolic and pathological conditions and which proteins regulate this. Here, we summarize recent exciting discoveries about the reorganization of organelle contacts in steatotic liver, including the identification of novel LD contact site proteins in cell lines and in animals. We also discuss state of the art proteomics workflows that enable the characterization of LD-organelle contacts and tethering proteins and give an outlook how this can inform obesity research.
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Publication type
Article: Journal article
Document type
Review
Keywords
Contact Site ; Lipid Droplet ; Nonalcoholic Fatty Liver Disease ; Phosphoproteome ; Proteomics ; Steatosis
ISSN (print) / ISBN
2515-2564
e-ISSN
2515-2564
Journal
Contact
Quellenangaben
Volume: 2
Publisher
Sage
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Obesity (IDO)