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Wang, X. ; Malinowski, A.R. ; Beckenbauer, J. ; Siehler, J. ; Blöchinger, A. ; Meitinger, T. ; Häring, H.-U. ; Staiger, H. ; Burtscher, I. ; Lickert, H.

Generation of a human induced pluripotent stem cell line (HMGUi002-A) from a healthy male individual.

Stem Cell Res. 39:101531 (2019)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Induced pluripotent stem cells (iPSCs) can be used to generate different somatic cell types in vitro, including insulin-producing pancreatic beta-cells. Here, we have generated iPSCs from a healthy male individual using an episomal reprogramming method. The resulting iPSCs are integration-free, have a normal karyotype and are pluripotent in vitro and in vivo. Furthermore, we show that this iPSC line can be differentiated into pancreatic lineage cells. Taken together, this iPSC line will be useful to test differentiation protocols towards beta-cell as well as other cell types and will also serve as a control for drug development and disease modelling studies.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
ISSN (print) / ISBN 1873-5061
e-ISSN 1876-7753
Journal Stem Cell Research
Quellenangaben Volume: 39, Issue: , Pages: , Article Number: 101531 Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
Institute of Human Genetics (IHG)
Institute of Diabetes Research and Metabolic Diseases (IDM)