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Hamelmann, E.* ; von Mutius, E. ; Bush, A.* ; Szefler, S.J.*

Addressing the risk domain in the long-term management of pediatric asthma.

Pediatr. Allergy Immunol. 31, 233-242 (2019)
Publ. Version/Full Text Postprint DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
There is growing concern regarding the long-term outcomes of early and poorly controlled childhood asthma, either of which can potentially lead to the development of severe asthma in adults and irrecoverable loss of lung function leading to chronic obstructive pulmonary disease. These outcomes of inadequately controlled asthma should prompt a change in practice to better and/or earlier identify children at risk of adverse respiratory outcomes of asthma, to monitor disease progression, and to design intervention strategies that could either prevent or reverse asthma progression in children. The careful follow-up of spirometry over time-in the form of lung function trajectories, the application of biomarkers to assist in the diagnosis of early asthma and medication selection for these patients, as well as methods to identify patients at risk of asthma attacks-can be used to develop individualized management strategies for children with asthma. It is now time for asthma specialists to communicate this information to patients, parents, and primary care physicians and to incorporate them into routine clinical assessments of children with asthma. In time, these concepts of risk management and prevention can be refined to provide a more comprehensive approach to asthma care so as to prevent adverse respiratory outcomes from poorly controlled childhood asthma.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Asthma ; Biomarkers ; Children ; Disease Management ; Disease Progression ; Early Intervention ; Risk Assessment ; Risk Management ; Spirometry; Exhaled Nitric-oxide; Host Rna Signature; Lung-function; Persistent Asthma; Childhood Asthma; Rhinovirus C; School-age; Exacerbations; Children; Infection
ISSN (print) / ISBN 0905-6157
e-ISSN 1399-3038
Journal Pediatric Allergy and Immunology
Quellenangaben Volume: 31, Issue: 3, Pages: 233-242 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Asthma and Allergy Prevention (IAP)