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Open Access Green as soon as Postprint is submitted to ZB.
The chemical basis of ferroptosis.
Nat. Chem. Biol. 15, 1137-1147 (2019)
Lipid peroxidation underlies the mechanism of oxidative cell death now known as ferroptosis. This modality, distinct from other forms of cell death, has been intensely researched in recent years owing to its relevance in both degenerative disease and cancer. The demonstration that it can be modulated by small molecules in multiple pathophysiological contexts offers exciting opportunities for novel pharmacological interventions. Herein, we introduce the salient features of lipid peroxidation, how it can be modulated by small molecules and what principal aspects require urgent investigation by researchers in the field. The central role of non-enzymatic reactions in the execution of ferroptosis will be emphasized, as these processes have hitherto not been generally considered 'druggable'. Moreover, we provide a critical perspective on the biochemical mechanisms that contribute to cell vulnerability to ferroptosis and discuss how they can be exploited in the design of novel therapeutics.
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Publication type
Article: Journal article
Document type
Review
Keywords
Polyunsaturated Fatty-acids; Cell-death; Lipid-peroxidation; Cancer-cells; Cystine/glutamate Antiporter; Oxidative Stress; Tumor-growth; Autoxidation; Mechanisms; Antioxidant
ISSN (print) / ISBN
1552-4450
e-ISSN
1552-4469
Journal
Nature Chemical Biology
Quellenangaben
Volume: 15,
Issue: 12,
Pages: 1137-1147
Publisher
Nature Publishing Group
Publishing Place
Basingstoke
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Developmental Genetics (IDG)