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Zaghlool, S.B.* ; Kühnel, B. ; Elhadad, M.A. ; Kader, S.* ; Halama, A.* ; Thareja, G.* ; Engelke, R.* ; Sarwath, H.* ; Al-Dous, E.K.* ; Mohamoud, Y.A.* ; Meitinger, T. ; Wilson, R. ; Strauch, K. ; Peters, A. ; Mook-Kanamori, D.O.* ; Graumann, J.* ; Malek, J.A.* ; Gieger, C. ; Waldenberger, M. ; Suhre, K.*

Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.

Nat. Commun. 11:15 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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DNA methylation and blood circulating proteins have been associated with many complex disorders, but the underlying disease-causing mechanisms often remain unclear. Here, we report an epigenome-wide association study of 1123 proteins from 944 participants of the KORA population study and replication in a multi-ethnic cohort of 344 individuals. We identify 98 CpG-protein associations (pQTMs) at a stringent Bonferroni level of significance. Overlapping associations with transcriptomics, metabolomics, and clinical endpoints suggest implication of processes related to chronic low-grade inflammation, including a network involving methylation of NLRC5, a regulator of the inflammasome, and associated pQTMs implicating key proteins of the immune system, such as CD48, CD163, CXCL10, CXCL11, LAG3, FCGR3B, and B2M. Our study links DNA methylation to disease endpoints via intermediate proteomics phenotypes and identifies correlative networks that may eventually be targeted in a personalized approach of chronic low-grade inflammation.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Differential Dna Methylation; Body-mass Index; Mhc Class-i; Papp-a; Biomarker Discovery; Expression; Complex; Identification; Metabolomics; Inflammation
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 11, Issue: 1, Pages: , Article Number: 15 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
Institute of Human Genetics (IHG)
Institute of Genetic Epidemiology (IGE)
POF-Topic(s) 30202 - Environmental Health
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504091-001
G-500700-001
G-504100-001
G-504000-010
G-504090-001
DOI 10.1038/s41467-019-13831-w
WOS ID WOS:000551404400001
Scopus ID 85077479889
PubMed ID 31900413
Erfassungsdatum 2020-02-27
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