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Soft ultrasound priors in optoacoustic reconstruction: Improving clinical vascular imaging.
Photoacoustics 19:100172 (2020)
Using the same ultrasound detector, hybrid optoacoustic-ultrasound (OPUS) imaging provides concurrent scans of tissue slices or volumes and visualizes complementary sound- and light-based contrast at similar resolutions. In addition to the benefit of hybrid contrast, spatial co-registration enables images from one modality to be employed as prior information for improving an aspect of the performance of the other modality. We consider herein a handheld OPUS system and utilize structural information from ultrasound images to guide regional Laplacian regularization-based reconstruction of optoacoustic images. Using phantoms and data from OPUS scans of human radial and carotid arteries, we show that ultrasound-driven optoacoustic inversion reduces limited-view artefacts and improves image contrast. In phantoms, prior-integrated reconstruction leads to a 50 % higher contrast-to-noise ratio (CNR) of the image than standard reconstruction, and a 17 % higher structural similarity (SSIM) index. In clinical data, prior-integrated reconstruction detects deep-seated radial arteries with higher CNR than the standard method at three different depths. In this way, the prior-integrated method offers unique insights into atherosclerotic carotid plaques in humans (with p < 0.01 between patients and healthy volunteers), potentially paving the way for new abilities in vascular imaging and more generally in optoacoustic imaging.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Photoacoustics ; Hybrid Imaging ; Regional Laplacian Regularization ; Carotid ; Radial Artery; Photoacoustic Tomography; Acoustic Inversion; System; Fluorescence; Visibility; Projection; Artifacts
ISSN (print) / ISBN
2213-5979
Journal
Photoacoustics
Quellenangaben
Volume: 19,
Article Number: 100172
Publisher
Elsevier
Publishing Place
Hackerbrucke 6, 80335 Munich, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Grants
Alexander von Humboldt Postdoctoral Fellowship program
CSC
Deutsche Forschungsgemeinschaft DFG, Germany
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme
CSC
Deutsche Forschungsgemeinschaft DFG, Germany
European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme