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Pesce, G.* ; Triebner, K.* ; van der Plaat, D.A.* ; Courbon, D.* ; Hustad, S.* ; Sigsgaard, T.* ; Nowak, D.* ; Heinrich, J. ; Antò, J.M.* ; Dorado-Arenas, S.* ; Martinez-Moratalla, J.* ; Gullon-Blanco, J.A.* ; Sánchez-Ramos, J.L.* ; Raherison, C.* ; Pin, I.* ; Demoly, P.* ; Gislason, T.* ; Torén, K.* ; Forsberg, B.* ; Lindberg, E.* ; Zemp, E.* ; Jogi, R.* ; Probst-Hensch, N.* ; Dharmage, S.C.* ; Jarvis, D.* ; Garcia-Aymerich, J.* ; Marcon, A.* ; Gómez-Real, F.* ; Leynaert, B.*

Low serum DHEA-S is associated with impaired lung function in women.

EClinicalMedicine 23:100389 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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Background: Emerging evidence suggests that androgens and estrogens have a role in respiratory health, but it is largely unknown whether levels of these hormones can affect lung function in adults from the general population. This study investigated whether serum dehydroepiandrosterone sulfate (DHEA-S), a key precursor of both androgens and estrogens in peripheral tissues, was related to lung function in adult women participating in the European Community Respiratory Health Survey (ECRHS). Methods: Lung function and serum DHEA-S concentrations were measured in n = 2,045 and n = 1,725 women in 1999-2002 and in 2010-2013, respectively. Cross-sectional associations of DHEA-S levels (expressed as age-adjusted z-score) with spirometric outcomes were investigated, adjusting for smoking habits, body mass index, menopausal status, and use of corticosteroids. Longitudinal associations of DHEA-S levels in 1999-2002 with incidence of restrictive pattern and airflow limitation in 2010-2013 were also assessed. Findings: Women with low DHEA-S (z-score<-1) had lower FEV1 (% of predicted, adjusted difference: -2.2; 95%CI: -3.5 to -0.9) and FVC (-1.7; 95%CI: -2.9 to -0.5) and were at a greater risk of having airflow limitation and restrictive pattern on spirometry than women with higher DHEA-S levels. In longitudinal analyses, low DHEA-S at baseline was associated with a greater incidence of airflow limitation after an 11-years follow-up (incidence rate ratio, 3.43; 95%CI: 1.91 to 6.14). Interpretation: Low DHEA-S levels in women were associated with impaired lung function and a greater risk of developing airflow limitation later in adult life. Our findings provide new evidence supporting a role of DHEA-S in respiratory health. Funding: EU H2020, grant agreement no.633212.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Airflow Obstruction ; Androgens ; Cohort Studies ; Sex Hormones; Follow-up; Health; Dehydroepiandrosterone; Mortality; Blood; Age; Testosterone; Suppression; Steroids; Axis
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 2589-5370
e-ISSN 2589-5370
Journal EClinicalMedicine
Quellenangaben Volume: 23, Issue: , Pages: , Article Number: 100389 Supplement: ,
Publisher Springer
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-008
Grants INSERM U700
European Commission
Medical Research Council
Norwegian Research Council
ECRHS Paris team
Comite National contre les Maladies Respiratoires (CNMR)
centre d'lnvestigation Clinique (CIC)
Bichat Hospital
French Agence Nationale de la Recherche (ANR)
European Union
DOI 10.1016/j.eclinm.2020.100389
WOS ID WOS:000645949700022
Scopus ID 85085746895
PubMed ID 32529179
Erfassungsdatum 2020-06-15
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