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Open Access Green as soon as Postprint is submitted to ZB.
The stem cell potential of glia: Lessons from reactive gliosis.
Nat. Rev. Neurosci. 12, 88-104 (2011)
Astrocyte-like cells, which act as stem cells in the adult brain, reside in a few restricted stem cell niches. However, following brain injury, glia outside these niches acquire or reactivate stem cell potential as part of reactive gliosis. Recent studies have begun to uncover the molecular pathways involved in this process. A comparison of molecular pathways activated after injury with those involved in the normal neural stem cell niches highlights strategies that could overcome the inhibition of neurogenesis outside the stem cell niche and instruct parenchymal glia towards a neurogenic fate. This new view on reactive glia therefore suggests a widespread endogenous source of cells with stem cell potential, which might potentially be harnessed for local repair strategies.
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Publication type
Article: Journal article
Document type
Review
Keywords
central-nervous-system; epidermal-growth-factor; spinal-cord-injury; neural stem/progenitor cells; adult-rat brain; oligodendrocyte precursor cells; subventricular zone astrocytes; bone morphogenetic proteins; in-vitro; cerebral-cortex
ISSN (print) / ISBN
1471-003X
e-ISSN
1471-0048
Journal
Nature Reviews - Neuroscience
Quellenangaben
Volume: 12,
Issue: 2,
Pages: 88-104
Publisher
Nature Publishing Group
Publishing Place
London
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)