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The stem cell potential of glia: Lessons from reactive gliosis.
Nat. Rev. Neurosci. 12, 88-104 (2011)
Astrocyte-like cells, which act as stem cells in the adult brain, reside in a few restricted stem cell niches. However, following brain injury, glia outside these niches acquire or reactivate stem cell potential as part of reactive gliosis. Recent studies have begun to uncover the molecular pathways involved in this process. A comparison of molecular pathways activated after injury with those involved in the normal neural stem cell niches highlights strategies that could overcome the inhibition of neurogenesis outside the stem cell niche and instruct parenchymal glia towards a neurogenic fate. This new view on reactive glia therefore suggests a widespread endogenous source of cells with stem cell potential, which might potentially be harnessed for local repair strategies.
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Publication type
Article: Journal article
Document type
Review
Keywords
central-nervous-system; epidermal-growth-factor; spinal-cord-injury; neural stem/progenitor cells; adult-rat brain; oligodendrocyte precursor cells; subventricular zone astrocytes; bone morphogenetic proteins; in-vitro; cerebral-cortex
Language
english
Publication Year
2011
HGF-reported in Year
2011
ISSN (print) / ISBN
1471-003X
e-ISSN
1471-0048
Journal
Nature Reviews - Neuroscience
Quellenangaben
Volume: 12,
Issue: 2,
Pages: 88-104
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
POF-Topic(s)
30204 - Cell Programming and Repair
Research field(s)
Stem Cell and Neuroscience
PSP Element(s)
G-500800-001
PubMed ID
21248788
DOI
10.1038/nrn2978
Scopus ID
78751677843
Erfassungsdatum
2011-05-10