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Shahryaria, A. ; Moya, N. ; Siehler, J. ; Wang, X. ; Blöchinger, A. ; Burtscher, I. ; Bakhti, M. ; Mowla, S.J.* ; Lickert, H.

Generation of a human iPSC line harboring a biallelic large deletion at the INK4 locus (HMGUi001-A-5).

Stem Cell Res. 47:101927 (2020)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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The INK4 locus is considered as a hot-spot region for the complex genetic disorders, including cancer, type 2 diabetes (T2D) and coronary artery disease (CAD). By CRISPR/Cas9 gene editing, we generated a human induced pluripotent stem cell (hiPSC) line (HMGUi001-A-5) deleting an 8 kb genomic DNA encompassing six T2D-associated SNPs at the INK4 locus. The resulting hiPSC line revealed a normal karyotype, preserved pluripotency and was able to differentiate towards germ layers, endoderm, mesoderm and ectoderm. Thus, the HMGUi001-A-5 line could provide a valuable cellular model to explore the molecular mechanisms linking these SNPs to T2D and other genetic disorders.
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Publication type Article: Journal article
Document type Scientific Article
Language english
Publication Year 2020
HGF-reported in Year 2020
ISSN (print) / ISBN 1873-5061
e-ISSN 1876-7753
Journal Stem Cell Research
Quellenangaben Volume: 47, Issue: , Pages: , Article Number: 101927 Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Regeneration Research (IDR)
Institute of Stem Cell Research (ISF)
POF-Topic(s) 30201 - Metabolic Health
90000 - German Center for Diabetes Research
30204 - Cell Programming and Repair
Research field(s) Helmholtz Diabetes Center
Stem Cell and Neuroscience
PSP Element(s) G-502300-001
G-501900-231
G-500800-001
Grants Deutsches Zentrum fur Diabetesforschung (DZD)
Helmholtz-Gemeinschaft (Helmholtz Portfolio Theme 'Metabolic Dysfunction and Common Disease)
Iran Ministry of Science and Technology (Tarbiat Modares University)
DOI 10.1016/j.scr.2020.101927
WOS ID WOS:000566517800006
Scopus ID 85088801931
PubMed ID 32739881
Erfassungsdatum 2020-10-07
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