Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
PMC
 |
Open Access Gold (Paid Option) |
|
as soon as is submitted to ZB.
The making of insulin in health and disease.
Diabetologia 63, 1981-1989 (2020)
The discovery of insulin in 1921 has been one of greatest scientific achievements of the 20th century. Since then, the availability of insulin has shifted the focus of diabetes treatment from trying to keep patients alive to saving and improving the life of millions. Throughout this time, basic and clinical research has advanced our understanding of insulin synthesis and action, both in healthy and pathological conditions. Yet, multiple aspects of insulin production remain unknown. In this review, we focus on the most recent findings on insulin synthesis, highlighting their relevance in diabetes.Graphical abstract
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Beta Cell ; Insulin Biosynthesis ; Insulin Maturation ; Post-transcriptional Regulation ; Proinsulin Conversion ; Review ; Type 1 Diabetes ; Type 2 Diabetes; Endoplasmic-reticulum Stress; Rat Pancreatic-islets; Messenger-rna; Translational Control; Diabetes-mellitus; Er Stress; Proinsulin Synthesis; Granule Proteins; Gene-expression; Beta-cells
ISSN (print) / ISBN
0012-186X
e-ISSN
1432-0428
Journal
Diabetologia
Quellenangaben
Volume: 63,
Issue: 10,
Pages: 1981-1989
Publisher
Springer
Publishing Place
Berlin ; Heidelberg [u.a.]
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Pancreatic Islet Research (IPI)
Grants
EU-IMI (INNODIA)
EU-IMI (RHAPSODY)
EU-IMI (RHAPSODY)