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Neuronal reprogramming for brain repair: Challenges and perspectives.
Trends Mol. Med. 26, 890-892 (2020)
Brain injuries and neurodegenerative diseases elicit neuronal loss that persists because the adult mammalian brain lacks robust regenerative abilities. Direct reprogramming of local glial cells into neurons is a promising strategy for neuronal replacement in vivo. We discuss recent advances and future challenges in this approach to brain repair.
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Publication type
Article: Journal article
Document type
Review
Keywords
Astrocytes ; Brain Repair ; Neuronal Loss ; Neuronal Reprogramming; Conversion; Disease; Glia
ISSN (print) / ISBN
1471-4914
e-ISSN
1471-499X
Journal
Trends in Molecular Medicine
Quellenangaben
Volume: 26,
Issue: 10,
Pages: 890-892
Publisher
Elsevier
Publishing Place
The Boulevard, Langford Lane, Kidlington, Oxford Ox5 1gb, Oxon, England
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)
Grants
SyNergy Excellence Cluster
Swiss National Science Foundation (SNSF) post-doctoral fellowship
European Research Council (ERC) grant ChroNeuroRepair
Roger de Spoelberch Foundation
Micronet (Era-Net)
German Research Foundation
Swiss National Science Foundation (SNSF) post-doctoral fellowship
European Research Council (ERC) grant ChroNeuroRepair
Roger de Spoelberch Foundation
Micronet (Era-Net)
German Research Foundation