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Cuellar-Partida, G.* ; Eriksson, N.* ; Albrecht, E. ; Aliev, F.* ; Andreassen, O.A.* ; Barroso, I.* ; Beckmann, J.S.* ; Boks, M.P.* ; Boomsma, D.I.* ; Boyd, H.A.* ; Breteler, M.M.B.* ; Campbell, H.* ; Chasman, D.I.* ; Cherkas, L.F.* ; Davies, G.* ; de Geus, E.J.C.* ; Deary, I.J.* ; Deloukas, P.* ; Dick, D.M.* ; Duffy, D.L.* ; Eriksson, J.G.* ; Esko, T.* ; Feenstra, B.* ; Geller, F.* ; Gieger, C. ; Giegling, I.* ; Gordon, S.D.* ; Han, J.* ; Hansen, T.F.* ; Hartmann, A.M.* ; Hayward, C.* ; Heikkilä, K.* ; Hicks, A.A.* ; Hirschhorn, J.N.* ; Hottenga, J.J.* ; Huffman, J.E.* ; Hwang, L.D.* ; Ikram, M.A.* ; Kaprio, J.* ; Kemp, J.P.* ; Khaw, K.T.* ; Klopp, N.* ; Konte, B.* ; Kutalik, Z.* ; Lahti, J.* ; Li, X.* ; Loos, R.J.F.* ; Luciano, M.* ; Magnusson, S.H.* ; Mangino, M.* ; Marques-Vidal, P.M.* ; Martin, N.G.* ; McArdle, W.L.* ; McCarthy, M.I.* ; Medina-Gomez, C.* ; Melbye, M.* ; Melville, S.A.* ; Metspalu, A.* ; Milani, L.* ; Mooser, V.* ; Nelis, M.* ; Nyholt, D.R.* ; O’Connell, K.S.* ; Ophoff, R.A.* ; Palmer, C.* ; Palotie, A.* ; Palviainen, T.* ; Paré, G.* ; Paternoster, L.* ; Peltonen, L.* ; Penninx, B.W.J.H.* ; Polasek, O.* ; Pramstaller, P.P.* ; Prokopenko, I.* ; Räikkönen, K.* ; Ripatti, S.* ; Rivadeneira, F.* ; Rudan, I.* ; Rujescu, D.* ; Smit, J.H.* ; Smith, G.D.* ; Smoller, J.W.* ; Soranzo, N.* ; Spector, T.D.* ; Pourcain, B.S.* ; Starr, J.M.* ; Stefánsson, H.* ; Steinberg, S.* ; Teder-Laving, M.* ; Thorleifsson, G.* ; Stefánsson, K.* ; Timpson, N.J.* ; Uitterlinden, A.G.* ; van Duijn, C.M.* ; van Rooij, F.J.A.* ; Vink, J.M.* ; Vollenweider, P.* ; Vuoksimaa, E.* ; Waeber, G.* ; Wareham, N.J.* ; Warrington, N.* ; Waterworth, D.* ; Werge, T.* ; Wichmann, H.-E. ; Widen, E.* ; Willemsen, G.* ; Wright, A.F.* ; Wright, M.J.* ; Xu, M.* ; Zhao, J.H.* ; Kraft, P.* ; Hinds, D.A.* ; Lindgren, C.M.* ; Mägi, R.* ; Neale, B.M.* ; Evans, D.M* ; Medland, S.E.*

Genome-wide association study identifies 48 common genetic variants associated with handedness.

Nat. Hum. Behav. 5, 59–70 (2021)
Postprint DOI PMC
Open Access Green
Handedness has been extensively studied because of its relationship with language and the over-representation of left-handers in some neurodevelopmental disorders. Using data from the UK Biobank, 23andMe and the International Handedness Consortium, we conducted a genome-wide association meta-analysis of handedness (N = 1,766,671). We found 41 loci associated (P < 5 x 10(-8)) with left-handedness and 7 associated with ambidexterity. Tissue-enrichment analysis implicated the CNS in the aetiology of handedness. Pathways including regulation of microtubules and brain morphology were also highlighted. We found suggestive positive genetic correlations between left-handedness and neuropsychiatric traits, including schizophrenia and bipolar disorder. Furthermore, the genetic correlation between left-handedness and ambidexterity is low (r(G) = 0.26), which implies that these traits are largely influenced by different genetic mechanisms. Our findings suggest that handedness is highly polygenic and that the genetic variants that predispose to left-handedness may underlie part of the association with some psychiatric disorders.A genome-wide association study of 1.7 million individuals identified 41 genetic variants associated with left-handedness and 7 associated with ambidexterity. The genetic correlation between the traits was low, thereby implying different aetiologies.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Language Dominance; Linkage Analysis; Metaanalysis; Microtubule; Asymmetry; Autism; Lateralization; Schizophrenia; Origins; Screen
ISSN (print) / ISBN 2397-3374
e-ISSN 2397-3374
Journal Nature human behaviour
Quellenangaben Volume: 5, Issue: , Pages: 59–70 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Genetic Epidemiology (IGE)
Institute of Epidemiology II (EPI2)
Institute of Epidemiology (EPI)
Grants Research Institute for Diseases in the Elderly
Neuroscience Campus Amsterdam (NCA)
Amsterdam Public Health (APH)
KNAW Academy Professor Award
Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL)
NWO
Netherlands Organization for Scientific research (NWO)
Wellcome Trust
Oak Foundation
NHMRC Senior Research Fellowship
European Community 7th Framework Program (FP7/2007-2013): ENGAGE
European Community 7th Framework Program (FP7/2007-2013): ACTION
Genetic Laboratory of the Department of Internal Medicine, Erasmus MC
Netherlands Organisation of Scientific Research NWO Investments
Developmental Trajectories of Psychopathology
Grand Opportunity grants Integration of Genomics and Transcriptomics
Determinants of Adolescent Exercise Behavior
Major depression: stage 1 genome-wide association in population-based samples
Developmental Study of Attention Problems in Young Twins (NIMH)
Collaborative Study of the Genetics of DZ twinning
Rutgers University Cell and DNA Repository cooperative agreement
Australian National Health and Medical Research Council Early Career Fellowship
NIHR
Widenlife
NIHR Biomedical Research Centre, Oxford
WT-SSI/John Fell funds
Li Ka Shing Foundation
Australia Research Council Discovery Early Career Researcher Award
National Health and Medical Research Council Senior Research Fellowship
NIH
Estonian Research Council
Wellcome
Institute of Genomics, University of Tartu
University of Queensland
Netherlands Genomics Initiative (NGI)/Netherlands Organisation for Scientific Research (NWO) Netherlands Consortium for Healthy Aging (NCHA)
UK Medical Research Council
ENGAGE -European Network for Genetic and Genomic Epidemiology, FP7-HEALTH-F4-2007
Broad Institute
Wellcome Trust Sanger Institute
Danish Medical Research Council
Lundbeck Foundation
Health Foundation
Augustinus Foundation
National Institute of Alcohol Abuse and Alcoholism
Academy of Finland
March of Dimes Birth Defects Foundation
Egmont Foundation
Novo Nordisk Foundation
Folkhalsan Research Foundation
Finnish Diabetes Research Society
Municipality of Rotterdam
European Commission (DG XII)
Ministry for Health, Welfare and Sports
Ministry of Education, Culture and Science
Research Institute for Diseases in the Elderly (RIDE)
Netherlands Organization for the Health Research and Development (ZonMw)
Erasmus University, Rotterdam
Finska Lakaresallskapet
Juho Vainio Foundation
Pharmacy Foundation
Danish National Research Foundation
Munich Center of Health Sciences (MC-Health), Ludwig-Maximilians-Universitat, as part of LMUinnovativ
State of Bavaria
Helmholtz Zentrum Munchen-German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
Emil Aaltonen Foundation
Ahokas Foundation
Ministry of Education
University of Helsinki
Signe and Ane Gyllenberg Foundation
Erasmus Medical Center, Rotterdam