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Jakob, C.E.M.* ; Borgmann, S.* ; Duygu, F.* ; Behrends, U. ; Hower, M.* ; Merle, U.* ; Friedrichs, A.* ; Tometten, L.* ; Hanses, F.* ; Jung, N.* ; Rieg, S.* ; Wille, K.* ; Grüner, B.* ; Klinker, H.* ; Gersbacher-Runge, N.* ; Hellwig, K.* ; Eberwein, L.* ; Dolff, S.* ; Rauschning, D.* ; von Bergwelt-Baildon, M.* ; Lanznaster, J.* ; Strauß, R.* ; Trauth, J.* ; de With, K.* ; Ruethrich, M.* ; Lueck, C.* ; Nattermann, J.* ; Tscharntke, L.* ; Pilgram, L.* ; Fuhrmann, S.* ; Classen, A.* ; Stecher, M.* ; Schons, M.* ; Spinner, C.* ; Vehreschild, J.J.*

First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)".

Infection 49, 63–73 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Purpose Knowledge regarding patients' clinical condition at severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) detection is sparse. Data in the international, multicenter Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS) cohort study may enhance the understanding of COVID-19. Methods Sociodemographic and clinical characteristics of SARS-CoV-2-infected patients, enrolled in the LEOSS cohort study between March 16, 2020, and May 14, 2020, were analyzed. Associations between baseline characteristics and clinical stages at diagnosis (uncomplicated vs. complicated) were assessed using logistic regression models. Results We included 2155 patients, 59.7% (1,287/2,155) were male; the most common age category was 66-85 years (39.6%; 500/2,155). The primary COVID-19 diagnosis was made in 35.0% (755/2,155) during complicated clinical stages. A significant univariate association between age; sex; body mass index; smoking; diabetes; cardiovascular, pulmonary, neurological, and kidney diseases; ACE inhibitor therapy; statin intake and an increased risk for complicated clinical stages of COVID-19 at diagnosis was found. Multivariable analysis revealed that advanced age [46-65 years: adjusted odds ratio (aOR): 1.73, 95% CI 1.25-2.42,p = 0.001; 66-85 years: aOR 1.93, 95% CI 1.36-2.74,p < 0.001; > 85 years: aOR 2.38, 95% CI 1.49-3.81,p < 0.001 vs. individuals aged 26-45 years], male sex (aOR 1.23, 95% CI 1.01-1.50,p = 0.040), cardiovascular disease (aOR 1.37, 95% CI 1.09-1.72,p = 0.007), and diabetes (aOR 1.33, 95% CI 1.04-1.69,p = 0.023) were associated with complicated stages of COVID-19 at diagnosis. Conclusion The LEOSS cohort identified age, cardiovascular disease, diabetes and male sex as risk factors for complicated disease stages at SARS-CoV-2 diagnosis, thus confirming previous data. Further data regarding outcomes of the natural course of COVID-19 and the influence of treatment are required.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Sars-cov-2 ; Covid-19 ; Leoss ; Cohort Study
ISSN (print) / ISBN 0300-8126
e-ISSN 1439-0973
Journal Infection - A Journal of Infectious Disease
Quellenangaben Volume: 49, Issue: , Pages: 63–73 Article Number: , Supplement: ,
Publisher Urban & Vogel
Publishing Place Tiergartenstrasse 17, D-69121 Heidelberg, Germany
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Gene Vector (AGV)
Grants Projekt DEAL