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Krautenbacher, N. ; Kabesch, M.* ; Horak, E.* ; Braun-Fahrländer, C.* ; Genuneit, J.* ; Boznanski, A.* ; von Mutius, E. ; Theis, F.J. ; Fuchs, C. ; Ege, M.J.* ; GABRIELA, PASTURE study groups*

Asthma in farm children is more determined by genetic polymorphisms and in non-farm children by environmental factors.

Pediatr. Allergy Immunol. 32, 295-304 (2021)

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Background: The asthma syndrome is influenced by hereditary and environmental factors. With the example of farm exposure, we study whether genetic and environmental factors interact for asthma. Methods: Statistical learning approaches based on penalized regression and decision trees were used to predict asthma in the GABRIELA study with 850 cases (9% farm children) and 857 controls (14% farm children). Single-nucleotide polymorphisms (SNPs) were selected from a genome-wide dataset based on a literature search or by statistical selection techniques. Prediction was assessed by receiver operating characteristics (ROC) curves and validated in the PASTURE cohort. Results: Prediction by family history of asthma and atopy yielded an area under the ROC curve (AUC) of 0.62 [0.57-0.66] in the random forest machine learning approach. By adding information on demographics (sex and age) and 26 environmental exposure variables, the quality of prediction significantly improved (AUC = 0.65 [0.61-0.70]). In farm children, however, environmental variables did not improve prediction quality. Rather SNPs related to IL33 and RAD50 contributed significantly to the prediction of asthma (AUC = 0.70 [0.62-0.78]). Conclusions: Asthma in farm children is more likely predicted by other factors as compared to non-farm children though in both forms, family history may integrate environmental exposure, genotype and degree of penetrance.

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