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Baumann, R.* ; Untersmayr, E.* ; Zissler, U.M. ; Eyerich, S. ; Adcock, I.M.* ; Brockow, K.* ; Biedermann, T.* ; Ollert, M.* ; Chaker, A. ; Pfaar, O.* ; Garn, H.* ; Thwaites, R.S.* ; Togias, A.* ; Kowalski, M.L.* ; Hansel, T.* ; Jakwerth, C.A. ; Schmidt-Weber, C.B.

Non-invasive and minimally-invasive techniques for the diagnosis and management of allergic diseases.

Allergy 76, 1010-1023 (2021)
Postprint Research data DOI PMC
Open Access Green
Allergic diseases of the (upper and lower) airways, the skin as well as the gastrointestinal tract, are on the rise, resulting in impaired quality of life, decreased productivity and increased healthcare costs. As allergic diseases are mostly tissue specific, local sampling methods for respective biomarkers offer the potential for increased sensitivity and specificity. Additionally, local sampling using non-invasive or minimally-invasive methods can be cost-effective and well tolerated, which may even be suitable for primary or home care sampling. Non- or minimally-invasive local sampling and diagnostics may enable a more thorough endotyping, may help to avoid under- or overdiagnosis, and may provide the possibility to approach precision prevention, due to early diagnosis of these local diseases even before they get systemically manifested and detectable. At the same time, dried blood samples may help to facilitate minimal-invasive primary or home care sampling for classical systemic diagnostic approaches. This EAACI position paper contains a thorough review of the various technologies in allergy diagnosis available on the market, which analytes or biomarkers are employed, and which samples or matrices can be used. Based on this assessment, EAACIs position is to drive these developments to efficiently identify allergy and possibly later also viral epidemics and take advantage of comprehensive knowledge to initiate preventions and treatments.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Anaphylaxis ; Asthma ; Atopic Dermatitis ; Food Allergy ; Non-invasive Diagnosis
ISSN (print) / ISBN 0105-4538
e-ISSN 1398-9995
Journal Allergy
Quellenangaben Volume: 76, Issue: 4, Pages: 1010-1023 Article Number: , Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute for Allergy Research (IAF)