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Schlett, C.L.* ; Rospleszcz, S. ; Korbmacher, D.* ; Lorbeer, R.* ; Auweter, S.* ; Hetterich, H.* ; Selder, S.* ; Heier, M. ; Linkohr, B. ; Weckbach, S.* ; Ertl-Wagner, B.* ; Peters, A. ; Bamberg, F.*

Incidental findings in whole-body MR imaging of a population-based cohort study: Frequency, management and psychosocial consequences.

Eur. J. Radiol. 134:109451 (2021)

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Objectives: Management of incidental findings (IF) remains controversial but highly relevant. Our aim was to assess the frequency, management and psychosocial consequences of IF reporting in a population-based cohort study undergoing whole-body MR imaging. Methods: The study was nested in a prospective cohort from a longitudinal, population-based cohort (KORA-FF4) in southern Germany. All MR obtained on 3 T MR scanner were reviewed by board-certified radiologists regarding clinically relevant IF. A baseline and follow-up questionnaires including PHQ-9 were completed prior to and 6-month after to the scan. Results: Of 400 participants (56.3 ± 9.2years, 58 % male) undergoing whole-body MR, IF were found in 22 % of participants (n = 89); most frequently located in the abdominal sequences. In the pre-scan survey, most participants stated as the motivation that they wanted to “contribute to a scientific purpose” (91 %), while “knowing whether I'm healthy” was the most frequent motivation reported 6 months post-scan (88 %). The desire for IF reporting increased over time (pre- vs. 6-months-post-scan), also for clinically less important IF (72 % vs. 84 %, p = 0.001). Regarding psychosocial impact, a small portion (3.4 %) reported that awaiting the IF report added “definitely” or “very probably” additional stress burden. Of participants with reported IF, 56.8 % classified the results as “very helpful”. In the post-scan survey moderate depression was observed in 3.3 % and severe depression in 1.2 %. This did not differ between participants with and without reported IF. Conclusion: In a cohort with whole-body MR imaging, the prevalence of IF was high. Participants considered reporting of IF highly important and added only minor psychological burden.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Epidemiologic Study ; Incidental Finding ; Patient Care Management ; Psychosocial Aspects ; Whole Body Imaging; Brain Mri

ISSN (print) / ISBN 0720-048X

e-ISSN 0720-048X

Journal European Journal of Radiology

Quellenangaben Volume: 134, Article Number: 109451

Publisher Elsevier

Publishing Place Elsevier House, Brookvale Plaza, East Park Shannon, Co, Clare, 00000, Ireland

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)

Grants State of Bavaria, Germany
Helmholtz Zentrum Munchen -German Research Center for Environmental Health - German Federal Ministry of Education and Research (BMBF)
German Research Foundation (DFG, Bonn, Germany)