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Villalba, A.* ; Götz, M. ; Borrell, V.*

The regulation of cortical neurogenesis.

Curr. Top. Dev. Biol. 142, 1-66 (2020)

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Open Access Green as soon as Postprint is submitted to ZB.

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The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum complexity in terms of neuron number, diversity and functional circuitry. The emergence of this outstanding complexity begins during embryonic development, when a limited number of neural stem and progenitor cells manage to generate myriads of neurons in the appropriate numbers, types and proportions, in a process called neurogenesis. Here we review the current knowledge on the regulation of cortical neurogenesis, beginning with a description of the types of progenitor cells and their lineage relationships. This is followed by a review of the determinants of neuron fate, the molecular and genetic regulatory mechanisms, and considerations on the evolution of cortical neurogenesis in vertebrates leading to humans. We finish with an overview on how dysregulation of neurogenesis is a leading cause of human brain malformations and functional disabilities.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords Apical Adherens Junction ; Ferret ; Folding ; Intermediate Progenitor Cell ; Pax6 ; Radial Glia; Radial Glial-cells; Neural Stem-cells; Outer Subventricular Zone; Intermediate Progenitor Cells; Developing Cerebral-cortex; Central-nervous-system; Neocortical Projection Neurons; Protein Response Contributes; Messenger-rna Transport; Transcription Factor

ISSN (print) / ISBN 0070-2153

e-ISSN 1557-8933

Journal Current Topics in Developmental Biology

Quellenangaben Volume: 142, Pages: 1-66

Publisher Elsevier

Publishing Place 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Stem Cell Research (ISF)

Grants "Severo Ochoa" Programme for Centers of Excellence in RD
ERC Advanced Grant ChroNeuroRepair
Spanish State Research Agency
ERC Consolidator Grant CORTEXFOLDING