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Xeno-hybrid bone graft releasing biomimetic proteins promotes osteogenic differentiation of hMSCs.
Front. Cell Dev. Biol. 8:619111 (2020)
Bone defect is a noteworthy health problem and is the second most transplanted tissue after blood. Numerous bone grafts are designed and applied in clinics. Limitations, however, from different aspects still exist, including limited supply, mechanical strength, and bioactivity. In this study, two biomimetic peptides (P2 and P6) are incorporated into a composite bioactive xeno hybrid bone graft named SmartBonePep®, with the aim to increase the bioactivity of the bone graft. The results, which include cytotoxicity, proliferation rate, confocal microscopy, gene expression, and protein qualification, successfully prove that the SmartBonePep® has multi-modal biological effects on human mesenchymal stem cells from bone marrow. The effective physical entrapment of P6 into a composite xeno-hybrid bone graft, withstanding manufacturing processes including exposure to strong organic solvents and ethylene oxide sterilization, increases the osteogenic potential of the stem cells as well as cell attachment and proliferation. P2 and P6 both show a strong biological potential and may be future candidates for enhancing the clinical performance of bone grafts.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bioactive Proteins ; Bone Graft ; Bone Regeneration Biomimetic ; Bone Scaffold ; Intrinsically Disordered ; Mesenchymal Stem Cells ; Xenograft; Anorganic Bovine Bone; Morphogenetic Protein-2; Mechanical-properties; Synthetic Peptides; Substitutes; Biomaterials; Scaffolds; Growth; Defect; Amelogenin
Language
english
Publication Year
2020
HGF-reported in Year
2020
ISSN (print) / ISBN
2296-634X
e-ISSN
2296-634X
Quellenangaben
Volume: 8,
Article Number: 619111
Publisher
Frontiers
Publishing Place
Lausanne
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)
POF-Topic(s)
30205 - Bioengineering and Digital Health
Research field(s)
Enabling and Novel Technologies
PSP Element(s)
G-503800-001
Grants
EU Horizon 2020 MSCARISE-2018-Research and Innovation Staff Exchange programme project IP Osteo "Induced pluripotent stem cell for bone and cartilage defects"
China Scholarship Council
National Key Research and Development Program of China
Eureka Eurostars Project
China Scholarship Council
National Key Research and Development Program of China
Eureka Eurostars Project
WOS ID
WOS:000604734100001
Scopus ID
85099013632
PubMed ID
33415112
Erfassungsdatum
2021-01-15