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Karch, A.* ; Schindler, D.* ; Kühn-Steven, A. ; Blaser, R.* ; Kuhn, K.A.* ; Sandmann, L.* ; Sommerer, C.* ; Guba, M.* ; Heemann, U.* ; Strohäker, J.* ; Glöckner, S.* ; Mikolajczyk, R.* ; Busch, D.H.* ; Schulz, T.F.* ; Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium (Anton, G.) ; Transplant Cohort of the German Center for Infection Research (DZIF Transplant Cohort) Consortium (Wichmann, H.-E.)

The transplant cohort of the German center for infection research (DZIF Tx-Cohort): Study design and baseline characteristics.

Eur. J. Epidemiol. 36, 233–241 (2021)
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Infectious complications are the major cause of morbidity and mortality after solid organ and stem cell transplantation. To better understand host and environmental factors associated with an increased risk of infection as well as the effect of infections on function and survival of transplanted organs, we established the DZIF Transplant Cohort, a multicentre prospective cohort study within the organizational structure of the German Center for Infection Research. At time of transplantation, heart-, kidney-, lung-, liver-, pancreas- and hematopoetic stem cell- transplanted patients are enrolled into the study. Follow-up visits are scheduled at 3, 6, 9, 12 months after transplantation, and annually thereafter; extracurricular visits are conducted in case of infectious complications. Comprehensive standard operating procedures, web-based data collection and monitoring tools as well as a state of the art biobanking concept for blood, purified PBMCs, urine, and faeces samples ensure high quality of data and biosample collection. By collecting detailed information on immunosuppressive medication, infectious complications, type of infectious agent and therapy, as well as by providing corresponding biosamples, the cohort will establish the foundation for a broad spectrum of studies in the field of infectious diseases and transplant medicine. By January 2020, baseline data and biosamples of about 1400 patients have been collected. We plan to recruit 3500 patients by 2023, and continue follow-up visits and the documentation of infectious events at least until 2025. Information about the DZIF Transplant Cohort is available at https://www.dzif.de/en/working-group/transplant-cohort.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Clinical Cohort Study ; Immunosuppression ; Infection ; Organ Transplantation; Liver-transplant; Registries; Recipients; Mortality; Quality; Risk; Dna
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0393-2990
e-ISSN 1573-7284
Journal European Journal of Epidemiology
Quellenangaben Volume: 36, Issue: 2, Pages: 233–241 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504091-004
G-504000-009
Grants Bundesministerium für Forschung und Technologie
DOI 10.1007/s10654-020-00715-3
WOS ID WOS:000632064900009
WOS ID WOS:000611429900004
Scopus ID 85099950948
PubMed ID 33492549
Erfassungsdatum 2021-04-01
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