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Dietz, S.* ; Schwarz, J.* ; Rühle, J.* ; Schaller, M.* ; Fehrenbacher, B.* ; Marmé, A.* ; Schmid, E.* ; Peter, A. ; Poets, C.F.* ; Gille, C.* ; Köstlin-Gille, N.*

Extracellular vesicles released by myeloid-derived suppressor cells from pregnant women modulate adaptive immune responses.

Cell. Immunol. 361:104276 (2021)

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Open Access Green as soon as Postprint is submitted to ZB.

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Immunological pregnancy complications are a main challenge in reproductive medicine. Mechanisms regulating the adaptation of the maternal immune system to pregnancy are incompletely understood and therapeutic options limited. Myeloid derived suppressor cells (MDSC) are immune-modulatory cells expanding during healthy pregnancy and seem to play a crucial role for maternal-fetal tolerance. Recent studies showed that exosomes produced by MDSC have immune-modulatory effects corresponding to their parental cells under different pathological conditions. Here, we investigated immunological effects of exosomes of GR-MDSC during pregnancy. Isolated GR-MDSC exosomes from peripheral blood of pregnant women were tested for functionality in different in vitro assays. We show that GR-MDSC exosomes exhibited profound immune-modulatory effects such as suppression of T-cell proliferation, T helper 2 (Th2)-cell polarization, induction of regulatory T-cells and inhibition of lymphocyte cytotoxicity. Our results confirm that MDSC-derived exosomes functionally correspond to their parental cells and identify them as an interesting therapeutic target for immunological pregnancy complications.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Extracellular Vesicles ; Mdsc ; Pregnancy ; Th-cells ; Tregs

ISSN (print) / ISBN 0008-8749

e-ISSN 0008-8749

Journal Cellular Immunology

Quellenangaben Volume: 361, Article Number: 104276

Publisher Elsevier

Publishing Place 525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)

Grants German Center for Infection Research (DZIF)
Federal Ministry of Education and Research (BMBF)
German Research Foundation (DFG)
European Social Fund
Ministry for Science, Research and Art Baden-Wurttemberg (MWK-BW)
Medical Faculty of Tuebingen University