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Cannabis use does not impact on type 2 diabetes: A two-sample Mendelian randomization study.
Addict. Biol. 26:e13020 (2021)
Publ. Version/Full Text
Research data
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PMC
Cannabis has effects on the insulin/glucose metabolism. As the use of cannabis and the prevalence of type 2 diabetes increase worldwide, it is important to examine the effect of cannabis on the risk of diabetes. We conducted a Mendelian randomization (MR) study by using 19 single-nucleotide polymorphisms (SNPs) as instrumental variables for lifetime cannabis use and 14 SNPs to instrument cannabis use disorder and linking these to type 2 diabetes risk using genome-wide association study data (lifetime cannabis use [N = 184,765]; cannabis use disorder [2387 cases/48,985 controls], type 2 diabetes [74,124 cases/824,006 controls]). The MR analysis suggested no effect of lifetime cannabis use (inverse-variance weighted odds ratio [95% confidence interval] = 1.00 [0.93-1.09], P value = 0.935) and cannabis use disorder (OR = 1.03 [0.99-1.08]) on type 2 diabetes. Sensitivity analysis to assess potential pleiotropy led to no substantive change in the estimates. This study adds to the evidence base that cannabis use does not play a causal role in type 2 diabetes.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cannabis ; Diabetes
ISSN (print) / ISBN
1355-6215
e-ISSN
1369-1600
Journal
Addiction Biology
Quellenangaben
Volume: 26,
Issue: 6,
Article Number: e13020
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
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