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Niinistö, S.* ; Erlund, I.* ; Lee, H.S.* ; Uusitalo, U.* ; Salminen, I.* ; Aronsson, C.A.* ; Parikh, H.M.* ; Liu, X.* ; Hummel, S. ; Toppari, J.* ; She, J.X.* ; Lernmark, A.* ; Ziegler, A.-G. ; Rewers, M.* ; Akolkar, B.* ; Krischer, J.P.* ; Galas, D.* ; Das, S.* ; Sakhanenko, N.* ; Rich, S.S.* ; Hagopian, W.* ; Norris, J.M.* ; Virtanen, S.M.*

Children's erythrocyte fatty acids are associated with the risk of islet autoimmunity.

Sci. Rep. 11:3627 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Our aim was to investigate the associations between erythrocyte fatty acids and the risk of islet autoimmunity in children. The Environmental Determinants of Diabetes in the Young Study (TEDDY) is a longitudinal cohort study of children at high genetic risk for type 1 diabetes (n = 8676) born between 2004 and 2010 in the U.S., Finland, Sweden, and Germany. A nested case-control design comprised 398 cases with islet autoimmunity and 1178 sero-negative controls matched for clinical site, family history, and gender. Fatty acids composition was measured in erythrocytes collected at the age of 3, 6, and 12 months and then annually up to 6 years of age. Conditional logistic regression models were adjusted for HLA risk genotype, ancestry, and weight z-score. Higher eicosapentaenoic and docosapentaenoic acid (n - 3 polyunsaturated fatty acids) levels during infancy and conjugated linoleic acid after infancy were associated with a lower risk of islet autoimmunity. Furthermore, higher levels of some even-chain saturated (SFA) and monounsaturated fatty acids (MUFA) were associated with increased risk. Fatty acid status in early life may signal the risk for islet autoimmunity, especially n - 3 fatty acids may be protective, while increased levels of some SFAs and MUFAs may precede islet autoimmunity.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords De-novo Lipogenesis; Environmental Determinants; Amino-acid; Inflammation; Metabolism; Biomarkers; Discovery; Immunity; Health; Growth
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 11, Issue: 1, Pages: , Article Number: 3627 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research Type 1 (IDF)
Grants Academy of Finland
University of Colorado
NIH/NCATS Clinical and Translational Science Awards
JDRF
Centers for Disease Control and Prevention (CDC)
National Institute of Environmental Health Sciences (NIEHS)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
National Institute of Allergy and Infectious Diseases (NIAID)
National Institute of Diabetes and Digestive and Kidney diseases (NIDDK)