PuSH - Publication Server of Helmholtz Zentrum München: Relationship between atopic dermatitis, depression and anxiety: A two-sample mendelian randomization study.

Information

Clues to quality of journals

Open Access Policy of Helmholtz Association 2016

CC Licencences

Publication Metrics

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... HMGU-Authors/Consortia

... Organizational Structure

... Journal

... Publication Type

... Research Data

... Arbeitsgruppen

... Publication Year

Publication overview

Statistics

Statistics (last 5 years)

OA Publications

Publish

Submit Publication

Import publication from...

...EVA

Report missing publication

Highlights

Support & Contact

Contact persons

Help

Data protection

Helmholtz Open Science

JANE Journal Estimator

SHERPA/RoMEO

DOAJ

Export:

Text

Endnote (RIS) BIB

BibTeX

Baurecht, H.* ; Welker, C.* ; Baumeister, S. ; Weidnger, S.* ; Meisinger, C. ; Leitzmann, M.F.* ; Emmert, H.*

Relationship between atopic dermatitis, depression and anxiety: A two-sample mendelian randomization study.

Br. J. Dermatol. 185, 781–786 (2021)

Publ. Version/Full Text

Postprint

Research data

DOI

PMC

	Open Access Hybrid

Abstract
Metrics
Extra information

BACKGROUND: Growing evidence suggests that atopic dermatitis (AD) is associated with an increased risk of depressive disorders and anxiety. However, existing studies were observational and may uncover correlations but cannot easily disentangle non-causal or reverse-causal associations because these associations could be confounded and may not reflect true causal relationships. OBJECTIVES: We carried out a 2-sample Mendelian randomization (MR) study to examine the potential effect of AD on the risk of depressive disorders and anxiety. METHODS: Genetic instruments from the largest available genome-wide association study (GWAS) for AD (10,788 cases, 30,047 controls) were used to investigate the relation to broad depression (170,756 cases, 329,443 controls), major depressive disorder (MDD) (30,603 cases, 143,916 controls) and anxiety (5,580 cases, 11,730 controls). A set of complementary approaches were carried out to assess horizontal pleiotropy and related potential caveats occurring in MR studies. RESULTS: We observed no causal impact of AD on the risk of depressive disorders and anxiety, with close-to-zero effect estimates. The inverse weighted method revealed no associations of AD on broad depression (OR=1.014, P=0.4307), probable MDD (OR=1.004, P=0.5681), ICD-9/10-based MDD (OR=1.001, P=0.4659) or anxiety (OR=1.097, P=0.1801). CONCLUSIONS: In summary, this MR study does not support a causal effect of AD on depression and anxiety.

Impact Factor

Scopus SNIP

Scopus
Cited By

Altmetric

9.302

0.000