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Early age exposure to moisture and mould is related to FeNO at the age of 6 years.
Pediatr. Allergy Immunol. 32, 1226-1237 (2021)
Publ. Version/Full Text
Research data
DOI
PMC
BACKGROUND: Exposure to indoor moisture damage and visible mould has been found to be associated with asthma and respiratory symptoms in several questionnaire-based studies by self-report. We aimed to define the prospective association between the early life exposure to residential moisture damage or mould and fractional exhaled nitric oxide (FeNO) and lung function parameters as objective markers for airway inflammation and asthma in 6-year old children. METHODS: Home inspections were performed in children's homes when infants were on average 5 months old. At age 6 years, data on FeNO (n=322) as well as lung function (n=216) measurements were collected. Logistic regression and generalized additive models were used for statistical analyses. RESULTS: Early age major moisture damage and moisture damage or mould in the child's main living areas was significantly associated with increased FeNO levels (>75th percentile) at the age of 6 years (adjusted Odds Ratios, 95% Confidence Intervals, aOR (95%CI): 3.10 (1.35-7.07)) and 3.16 (1.43-6.98), respectively). Effects were more pronounced in those who did not change residential address throughout the study period. For lung function, major structural damage within the whole home was associated with reduced FEV1 and FVC, but not with FEV1/FVC. No association with lung function was observed with early moisture damage or mould in the child's main living areas. CONCLUSION: These results underline the importance of prevention and remediation efforts of moisture and mould damaged buildings in order to avoid harmful effects within the vulnerable phase of the infants and children's immunological development.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Asthma ; Cohort Study ; Exhaled No ; Lung Function ; Moisture Damage; Exhaled Nitric-oxide; Lung-function; Indoor Environment; Respiratory Health; Allergic Diseases; Asthma; Childhood; Symptoms; Damage; Children
ISSN (print) / ISBN
0905-6157
e-ISSN
1399-3038
Journal
Pediatric Allergy and Immunology
Quellenangaben
Volume: 32,
Issue: 6,
Pages: 1226-1237
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Grants
Finnish Cultural Foundation
Paivikki and Sakari Sohlberg Foundation
Competitive State Research Funding for the Kuopio University Hospital Catchment Area
Foundation for Pediatric Research
Juho Vainio Foundation
Academy of Finland
Paivikki and Sakari Sohlberg Foundation
Competitive State Research Funding for the Kuopio University Hospital Catchment Area
Foundation for Pediatric Research
Juho Vainio Foundation
Academy of Finland