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Blind source unmixing in multi-spectral optoacoustic tomography.
Opt. Express. 19, 3175-3184 (2011)
Multispectral optoacoustic (photoacoustic) tomography (MSOT) is a hybrid modality that can image through several millimeters to centimeters of diffuse tissues, attaining resolutions typical of ultrasound imaging. The method can further identify tissue biomarkers by decomposing the spectral contributions of different photo-absorbing molecules of interest. In this work we investigate the performance of blind source unmixing methods and spectral fitting approaches in decomposing the contributions of fluorescent dyes from the tissue background, based on MSOT measurements in mice. We find blind unmixing as a promising method for accurate MSOT decomposition, suitable also for spectral unmixing in fluorescence imaging. We further demonstrate its capacity with temporal unmixing on real-time MSOT data obtained in-vivo for enhancing the visualization of absorber agent flow in the mouse vascular system.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
gold nanorods; small animals; in-vivo; photoacoustic tomography; high-resolution; microscopy; pca
ISSN (print) / ISBN
1094-4087
e-ISSN
1094-4087
Journal
Optics Express
Quellenangaben
Volume: 19,
Issue: 4,
Pages: 3175-3184
Publisher
Optical Society of America (OSA)
Publishing Place
Washington, USA
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)