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Karabegović, I.* ; Portilla-Fernandez, E.* ; Li, Y.* ; Ma, J.* ; Maas, S.C.E.* ; Sun, D.* ; Hu, E.A.* ; Kühnel, B. ; Zhang, Y.* ; Ambatipudi, S.* ; Fiorito, G.* ; Huang, J.* ; Castillo-Fernandez, J.E.* ; Wiggins, K.L.* ; de Klein, N.* ; Grioni, S.* ; Swenson, B.R.* ; Polidoro, S.* ; Treur, J.L.* ; Cuenin, C.* ; Tsai, P.C.* ; Costeira, R.* ; Chajes, V.* ; Braun, K.* ; Verweij, N.* ; Kretschmer, A. ; Franke, L.* ; van Meurs, J.B.J.* ; Uitterlinden, A.G.* ; de Knegt, R.J.* ; Ikram, M.A.* ; Dehghan, A.* ; Peters, A. ; Schöttker, B.* ; Gharib, S.A.* ; Sotoodehnia, N.* ; Bell, J.T.* ; Elliott, P.* ; Vineis, P.* ; Relton, C.* ; Herceg, Z.* ; Brenner, H.* ; Waldenberger, M. ; Rebholz, C.M.* ; Voortman, T.* ; Pan, Q.* ; Fornage, M.* ; Levy, D.* ; Kayser, M.* ; Ghanbari, M.*

Epigenome-wide association meta-analysis of DNA methylation with coffee and tea consumption.

Nat. Commun. 12:2830 (2021)

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Coffee and tea are extensively consumed beverages worldwide which have received considerable attention regarding health. Intake of these beverages is consistently linked to, among others, reduced risk of diabetes and liver diseases; however, the mechanisms of action remain elusive. Epigenetics is suggested as a mechanism mediating the effects of dietary and lifestyle factors on disease onset. Here we report the results from epigenome-wide association studies (EWAS) on coffee and tea consumption in 15,789 participants of European and African-American ancestries from 15 cohorts. EWAS meta-analysis of coffee consumption reveals 11 CpGs surpassing the epigenome-wide significance threshold (P-value <1.1×10^-7), which annotated to the AHRR, F2RL3, FLJ43663, HDAC4, GFI1 and PHGDH genes. Among them, cg14476101 is significantly associated with expression of the PHGDH and risk of fatty liver disease. Knockdown of PHGDH expression in liver cells shows a correlation with expression levels of genes associated with circulating lipids, suggesting a role of PHGDH in hepatic-lipid metabolism. EWAS meta-analysis on tea consumption reveals no significant association, only two CpGs annotated to CACNA1A and PRDM16 genes show suggestive association (P-value <5.0×10^-6). These findings indicate that coffee-associated changes in DNA methylation levels may explain the mechanism of action of coffee consumption in conferring risk of diseases.

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Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Polycyclic Aromatic-hydrocarbons; Activated Receptor 4; Mendelian Randomization; Epigenetics; Risk; Population; Caffeine; Disease; Design; Cancer

ISSN (print) / ISBN 2041-1723

e-ISSN 2041-1723

Journal Nature Communications

Quellenangaben Volume: 12, Issue: 1, Article Number: 2830

Publisher Nature Publishing Group

Publishing Place London

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Epidemiology II (EPI2)

Grants Wellcome Trust
NCATS NIH HHS
Medical Research Council
Department of Health
NINDS NIH HHS
NIA NIH HHS
NHLBI NIH HHS
Biotechnology and Biological Sciences Research Council