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Khan Mirzaei, M. ; Deng, L.

New technologies for developing phage-based tools to manipulate the human microbiome.

Trends Microbiol. 30, 131-142 (2022)
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Gut bacteria play an essential role in the human body by regulating multiple functions, producing essential metabolites, protecting against pathogen invasion, and much more. Conversely, changes in their community structure are linked to several gastrointestinal (GI) and non-GI conditions. Fortunately, these bacteria are amenable to external perturbations, but we need specific tools for their safe manipulation as nonspecific changes can cause unpredicted long-term consequences. Here, we mainly discuss recent advances in cultivation-independent technologies and argue their relevance to different key steps, that is, identifying the modulation targets and developing phage-based tools to precisely modulate gut bacteria and restore a sustainable microbiome in humans. We finally suggest multiple modulating strategies for different dysbiosis-associated diseases.
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Publication type Article: Journal article
Document type Review
Keywords Cultivation-independent Technologies ; Microbiome Manipulation ; Multi-omics ; Phages ; Viral-tagging; Human Gut; Host-range; Bacteria; Metabolism; Bacteriophages; Cultivation; Resistance; Therapy; Patient
Language english
Publication Year 2022
Prepublished in Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 0966-842X
e-ISSN 1878-4380
Journal Trends in microbiology
Quellenangaben Volume: 30, Issue: 2, Pages: 131-142 Article Number: , Supplement: ,
Publisher Cell Press
Publishing Place Cambridge, Mass.
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-554300-001
Grants German Research Foundation (DFG Emmy Noether program)
European Research Council
DOI 10.1016/j.tim.2021.04.007
WOS ID WOS:000743513100007
Scopus ID 85106296780
PubMed ID 34016512
Erfassungsdatum 2021-06-18
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