Home
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
Publ. Version/Full Text
DOI
PMC
 |
Open Access Gold (Paid Option) |
|
as soon as is submitted to ZB.
New technologies for developing phage-based tools to manipulate the human microbiome.
Trends Microbiol. 30, 131-142 (2022)
Gut bacteria play an essential role in the human body by regulating multiple functions, producing essential metabolites, protecting against pathogen invasion, and much more. Conversely, changes in their community structure are linked to several gastrointestinal (GI) and non-GI conditions. Fortunately, these bacteria are amenable to external perturbations, but we need specific tools for their safe manipulation as nonspecific changes can cause unpredicted long-term consequences. Here, we mainly discuss recent advances in cultivation-independent technologies and argue their relevance to different key steps, that is, identifying the modulation targets and developing phage-based tools to precisely modulate gut bacteria and restore a sustainable microbiome in humans. We finally suggest multiple modulating strategies for different dysbiosis-associated diseases.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Review
Keywords
Cultivation-independent Technologies ; Microbiome Manipulation ; Multi-omics ; Phages ; Viral-tagging; Human Gut; Host-range; Bacteria; Metabolism; Bacteriophages; Cultivation; Resistance; Therapy; Patient
ISSN (print) / ISBN
0966-842X
e-ISSN
1878-4380
Journal
Trends in microbiology
Quellenangaben
Volume: 30,
Issue: 2,
Pages: 131-142
Publisher
Cell Press
Publishing Place
Cambridge, Mass.
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)
Grants
German Research Foundation (DFG Emmy Noether program)
European Research Council
European Research Council