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Interleukins in cancer: From biology to therapy.
Nat. Rev. Cancer 21, 481–499 (2021)
Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects. This Review aims to unravel some of these complex interactions.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cd4(+) T-cells; Phase-i Trial; Anti-interleukin-6 Monoclonal-antibody; Reduced Clinical Benefit; Natural-killer-cells; Colorectal-cancer; Multiple-myeloma; Siltuximab Anti-il-6; Il-15 Superagonist; Immune Activation
ISSN (print) / ISBN
1474-175X
e-ISSN
1474-1768
Journal
Nature Reviews - Cancer
Quellenangaben
Volume: 21,
Pages: 481–499
Publisher
Nature Publishing Group
Publishing Place
Heidelberger Platz 3, Berlin, 14197, Germany
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Unit for Clinical Pharmacology (KKG-EKLiP)
Grants
Jose Carreras Foundation
Hector foundation
Melanoma Research Alliance grant
Else Kroner-Fresenius-Stiftung
German Cancer Aid
international doctoral programme i Target: Immunotargeting of Cancer - Elite Network of Bavaria
Ernst-Jung-Stiftung
LMU Munich's institutional strategy LMU excellent within German Excellence Initiative
Bundesministerium fur Bildung und Forschung Project Oncoattract
European Research Council grant
German Research Foundation
Fritz Bender Foundation
Bavarian Ministry of Economical Affairs
Marie Skodowska-Curie Programme Training Network for the Immunotherapy of Cancer and Training Network for Optimizing Adoptive T Cell Therapy of Cancer - Horizon 2020 programme of the European Union
Hector foundation
Melanoma Research Alliance grant
Else Kroner-Fresenius-Stiftung
German Cancer Aid
international doctoral programme i Target: Immunotargeting of Cancer - Elite Network of Bavaria
Ernst-Jung-Stiftung
LMU Munich's institutional strategy LMU excellent within German Excellence Initiative
Bundesministerium fur Bildung und Forschung Project Oncoattract
European Research Council grant
German Research Foundation
Fritz Bender Foundation
Bavarian Ministry of Economical Affairs
Marie Skodowska-Curie Programme Training Network for the Immunotherapy of Cancer and Training Network for Optimizing Adoptive T Cell Therapy of Cancer - Horizon 2020 programme of the European Union