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Then, C. ; Herder, C. ; Then, H.* ; Thorand, B. ; Huth, C. ; Heier, M. ; Meisinger, C. ; Peters, A. ; Koenig, W.* ; Rathmann, W.* ; Roden, M.* ; Stumvoll, M.* ; Maalmi, H.* ; Meitinger, T.* ; Lechner, A. ; Scherberich, J.* ; Seissler, J.

Serum uromodulin is inversely associated with biomarkers of subclinical inflammation in the population-based KORA F4 study.

Clin. Kidney J. 14, 1618-1625 (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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Background: Uromodulin is a kidney-specific glycoprotein synthesized in tubular cells of Henle's loop exerting nephroprotective and immunomodulatory functions in the urinary tract. A small amount of uromodulin is also released into the systemic circulation, where its physiological role is unknown. Serum uromodulin (sUmod) has been associated with metabolic risk factors and with cardiovascular events and mortality, where these associations were partly stronger in men than in women. In this study, we investigated the associations of sUmod with biomarkers of subclinical inflammation in a population-based sample of women and men. Methods: Associations of sUmod with 10 biomarkers of subclinical inflammation were assessed in 1065 participants of the Cooperative Health Research in the Region of Augsburg (KORA) F4 study aged 62-81 years using linear regression models adjusted for sex, age, body mass index, estimated glomerular filtration rate and diabetes. Analyses were performed in the total study sample and stratified by sex. Results: sUmod was inversely associated with white blood cell count, high-sensitive C-reactive protein, interleukin (IL)-6, tumour necrosis factor-α, myeloperoxidase, superoxide dismutase-3, IL-1 receptor antagonist and IL-22 after multivariable adjustment and correction for multiple testing (P < 0.001 for each observation). There was a trend towards a stronger association of sUmod with pro-inflammatory markers in men than in women, with a significant P for sex interaction (<0.001) regarding the relation of sUmod with IL-6. Conclusions: sUmod was inversely associated with biomarkers of subclinical inflammation in older participants of the KORA F4 study. The association of sUmod with IL-6 differed between women and men. Future research should focus on whether the immunomodulatory properties of sUmod are one explanation for the association of sUmod with cardiovascular outcomes and mortality.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Immune Marker ; Immunology ; Serum Uromodulin ; Subclinical Inflammation ; Uromodulin; Tamm-horsfall Protein; Complement 1q; Glycoprotein; Risk; Antagonist; Activation; Mortality; Expression; Immunity
ISSN (print) / ISBN 2048-8505
e-ISSN 2048-8513
Journal Clinical Kidney Journal
Quellenangaben Volume: 14, Issue: 6, Pages: 1618-1625 Article Number: , Supplement: ,
Publisher Oxford University Press
Publishing Place Great Clarendon St, Oxford Ox2 6dp, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) CCG Biomarker for the subclassification of T2DM (KKG-KDB)
Institute of Epidemiology II (EPI2)
Independent Research Group Clinical Epidemiology (KEPI)
Grants German Research Foundation (DFG)
Clinical Cooperation Group Diabetes, Ludwig-Maximilians-University Munchen
Helmholtz Zentrum Munchen
German Diabetes Centre
Federal Ministry of Health (Berlin, Germany)
Ministry of Culture and Science of the state North-Rhine Westphalia (Dusseldorf, Germany)
Helmholtz Zentrum Munchen-German Research Centre for Environmental Health - German Federal Ministry of Education and Research (BMBF)
State of Bavaria
German Federal Ministry of Education and Research (BMBF)
Deutsche Diabetes Gesellschaft (DDG)
Virtual Diabetes Institute (Helmholtz Zentrum Munchen)