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Chronic inflammation mediates the association between cortisol and hyperglycemia: Findings from the cross-sectional population-based KORA Age Study.
J. Clin. Med. 10:2751 (2021)
Background: The study aimed to investigate the role of subclinical inflammation on the association between diurnal cortisol patterns and glycaemia in an aged population. (2) Methods: Salivary cortisol, interleukin-6 (IL-6) and glycated haemoglobin (HbA1c) were analysed in a sample of 394 men and 364 women (mean age = 5 ± 6.3, 65-90 years). The ratio of morning after awakening and late-night cortisol was calculated as an indication of diurnal cortisol slope (DCS). Multivariable regression models were run to examine whether IL-6 mediates the relationship between the DCS and glycaemia. The Sobel test and bootstrapping methods were used to quantify the mediation analyses. (3) Results: In comparison to normoglycaemic counterparts (n = 676, 89.2%), an increase in IL-6 concentrations, in individuals with hyperglycaemia (HbA1c ≥ 6.5%) (n = 82, 10.8%) (p = 0.04), was significantly associated with a flatter DCS. The link between flatter DCS and elevated HbA1c level was significant mediated by a heightened IL-6 level. Our results do not suggest reverse-directionality, whereby cortisol did not mediate the association of IL-6 with HbA1c. (4) Conclusions: In our sample, the relation between flatter DCS and hyperglycaemia was partly explained by IL-6 levels. The paradigm of subclinical inflammation-mediated cortisol response on glucose metabolism could have widespread implications for improving our understanding of the pathophysiology of type 2 diabetes mellitus.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Hba1c ; Cortisol ; Interleukin-6 ; Mediation Analysis ; Psychological Stress; Diurnal Salivary Cortisol; Psychological Stress; Cytokine Production; Interleukin-6; Sensitivity; Resistance; Profiles; Glycemia; Markers
ISSN (print) / ISBN
2077-0383
e-ISSN
2077-0383
Journal
Journal of Clinical Medicine
Quellenangaben
Volume: 10,
Issue: 13,
Article Number: 2751
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology II (EPI2)
Grants
Bundesministerium für Bildung und Forschung