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Rezende, F.* ; Malacarne, P.F.* ; Müller, N.* ; Rathkolb, B. ; Hrabě de Angelis, M. ; Schröder, K.* ; Brandes, R.P.*

Nox4 maintains blood pressure during low sodium diet.

Antioxidants 10:1103 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The NADPH oxidase Nox4 is a hydrogen peroxide (H2 O2)-producing enzyme, with the highest expression in the kidney. As the kidney is involved in volume and blood pressure control through sodium handling, we set out to determine the impact of a low sodium diet on these parameters in WT and Nox4-/-mice. Nox4 expression in the murine kidney was restricted to the proximal tubule. Nevertheless, low-sodium-induced weight loss and sodium sparing function was similar in WT and Nox4-/-mice, disputing an important function of renal Nox4 in sodium handling. In contrast, a low sodium diet resulted in a reduction in systolic blood pressure in Nox4-/-as compared to WT mice. This was associated with a selectively lower pressure to heart-rate ratio, as well as heart to body weight ratio. In general, a low sodium diet leads to activation of sympathetic tone and the renin angiotensin system, which subsequently increases peripheral resistance. Our observations suggest that the control by this system is attenuated in Nox4-/-mice, resulting in lower blood pressure in response to low sodium.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Nadph Oxidase 4 ; Proximal Tubule Cells ; Reactive Oxygen Species; Nadph-oxidase 4; Potential Vanilloid 1; Hypertension Role; Oxidative Stress; Contributes; Mechanisms; Expression; Reveals; Channel; Leads
ISSN (print) / ISBN 2076-3921
e-ISSN 2076-3921
Journal Antioxidants
Quellenangaben Volume: 10, Issue: 7, Pages: , Article Number: 1103 Supplement: ,
Publisher MDPI
Publishing Place St Alban-anlage 66, Ch-4052 Basel, Switzerland
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Grants SFB834
DFG RE 4360/2-1
SFB 815
German Center for Diabetes Research (DZD)
German Federal Ministry of Education and Research
DZHK, Partner Site RheinMain, Frankfurt
Heinrich und Fritz-Riese-Stiftung
Faculty of Medicine, Goethe-Universitat, Frankfurt am Main, Germany