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Differences in gut virome related to barrett esophagus and esophageal adenocarcinoma.
Microorganisms 9:1701 (2021)
The relationship between viruses (dominated by bacteriophages or phages) and lower gastrointestinal (GI) tract diseases has been investigated, whereas the relationship between gut bacteriophages and upper GI tract diseases, such as esophageal diseases, which mainly include Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), remains poorly described. This study aimed to reveal the gut bacteriophage community and their behavior in the progression of esophageal diseases. In total, we analyzed the gut phage community of sixteen samples from patients with esophageal diseases (six BE patients and four EAC patients) as well as six healthy controls. Differences were found in the community composition of abundant and rare bacteriophages among three groups. In addition, the auxiliary metabolic genes (AMGs) related to bacterial exotoxin and virulence factors such as lipopolysaccharides (LPS) biosynthesis proteins were found to be more abundant in the genome of rare phages from BE and EAC samples compared to the controls. These results suggest that the community composition of gut phages and functional traits encoded by them were different in two stages of esophageal diseases. However, the findings from this study need to be validated with larger sample sizes in the future.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Bacterial Exotoxin ; Esophageal Carcinogenesis ; Esophageal Diseases ; Gut Bacteriophages ; Lps Biosynthesis Proteins; Bacterial Biota; Bacteriophages; Microbiome; Viruses; Inflammation; Pathways; Health; Cancer
ISSN (print) / ISBN
2076-2607
e-ISSN
2076-2607
Journal
Microorganisms
Quellenangaben
Volume: 9,
Issue: 8,
Article Number: 1701
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Virology (VIRO)
Grants
Deutsche Krebshilfe Max Eder Program
European Research Council
German Research Foundation (DFG Emmy Noether program)
The Deutsche Krebshilfe Max Eder Program
European Research Council starting grant
European Research Council
German Research Foundation (DFG Emmy Noether program)
The Deutsche Krebshilfe Max Eder Program
European Research Council starting grant