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Miglis, M.G.* ; Adler, C.H.* ; Antelmi, E.* ; Arnaldi, D.* ; Baldelli, L.* ; Boeve, B.F.* ; Cesari, M.* ; Dall'Antonia, I.* ; Diederich, N.J.* ; Doppler, K.* ; Dušek, P.* ; Ferri, R.* ; Gagnon, J.F.* ; Gan-Or, Z.* ; Hermann, W.* ; Hoegl, B.* ; Hu, M.T.* ; Iranzo, A.* ; Janzen, A.* ; Kuzkina, A.* ; Lee, J.* ; Leenders, K.L.* ; Lewis, S.J.G.* ; Liguori, C.* ; Liu, J.* ; Lo, C.* ; Martens, K.A.E* ; Nepozitek, J.* ; Plazzi, G.* ; Provini, F.* ; Puligheddu, M.* ; Rolinski, M.* ; Rusz, J.* ; Stefani, A.* ; Summers, R.L.S.* ; Yoo, D.* ; Zitser, J.* ; Oertel, W.H.

Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.

Lancet Neurol. 20, 671-684 (2021)
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Open Access Green
Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving alpha-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal alpha-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest alpha-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of alpha-synucleinopathy patients with isolated RBD might develop.
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Publication type Article: Journal article
Document type Review
Keywords To-night Variability; Rem-sleep; Parkinsons-disease; Muscle-activity; Atonia Index; Identification; Deposits; Neurodegeneration; Association; Thresholds
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1474-4422
e-ISSN 1474-4422
Journal Lancet Neurology, The
Quellenangaben Volume: 20, Issue: 8, Pages: 671-684 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Neurogenomics (ING)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503200-001
Grants ParkinsonFonds Deutschland
Czech Health Research Council
US NIH
DOI 10.1016/S1474-4422(21)00176-9
WOS ID WOS:000677684700019
Scopus ID 85110583357
Erfassungsdatum 2021-09-09
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