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Miglis, M.G.* ; Adler, C.H.* ; Antelmi, E.* ; Arnaldi, D.* ; Baldelli, L.* ; Boeve, B.F.* ; Cesari, M.* ; Dall'Antonia, I.* ; Diederich, N.J.* ; Doppler, K.* ; Dušek, P.* ; Ferri, R.* ; Gagnon, J.F.* ; Gan-Or, Z.* ; Hermann, W.* ; Hoegl, B.* ; Hu, M.T.* ; Iranzo, A.* ; Janzen, A.* ; Kuzkina, A.* ; Lee, J.* ; Leenders, K.L.* ; Lewis, S.J.G.* ; Liguori, C.* ; Liu, J.* ; Lo, C.* ; Martens, K.A.E* ; Nepozitek, J.* ; Plazzi, G.* ; Provini, F.* ; Puligheddu, M.* ; Rolinski, M.* ; Rusz, J.* ; Stefani, A.* ; Summers, R.L.S.* ; Yoo, D.* ; Zitser, J.* ; Oertel, W.H.

Biomarkers of conversion to α-synucleinopathy in isolated rapid-eye-movement sleep behaviour disorder.

Lancet Neurol. 20, 671-684 (2021)

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Patients with isolated rapid-eye-movement sleep behaviour disorder (RBD) are commonly regarded as being in the early stages of a progressive neurodegenerative disease involving alpha-synuclein pathology, such as Parkinson's disease, dementia with Lewy bodies, or multiple system atrophy. Abnormal alpha-synuclein deposition occurs early in the neurodegenerative process across the central and peripheral nervous systems and might precede the appearance of motor symptoms and cognitive decline by several decades. These findings provide the rationale to develop reliable biomarkers that can better predict conversion to clinically manifest alpha-synucleinopathies. In addition, biomarkers of disease progression will be essential to monitor treatment response once disease-modifying therapies become available, and biomarkers of disease subtype will be essential to enable prediction of which subtype of alpha-synucleinopathy patients with isolated RBD might develop.

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Publication type Article: Journal article

Document type Review

Corresponding Author

Keywords To-night Variability; Rem-sleep; Parkinsons-disease; Muscle-activity; Atonia Index; Identification; Deposits; Neurodegeneration; Association; Thresholds

ISSN (print) / ISBN 1474-4422

e-ISSN 1474-4422

Journal Lancet Neurology, The

Quellenangaben Volume: 20, Issue: 8, Pages: 671-684

Publisher Elsevier

Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Neurogenomics (ING)

Grants ParkinsonFonds Deutschland
Czech Health Research Council
US NIH