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The role of innate immune cells in nonalcoholic fatty liver disease.
J. Innate Immun., 1-11 (2021)
Nonalcoholic fatty liver disease (NAFLD) is a very common hepatic pathology featuring steatosis and is linked to obesity and related conditions, such as the metabolic syndrome. When hepatic steatosis is accompanied by inflammation, the disorder is defined as nonalcoholic steatohepatitis (NASH), which in turn can progress toward fibrosis development that can ultimately result in cirrhosis. Cells of innate immunity, such as neutrophils or macrophages, are central regulators of NASH-related inflammation. Recent studies utilizing new experimental technologies, such as single-cell RNA sequencing, have revealed substantial heterogeneity within the macrophage populations of the liver, suggesting distinct functions of liver-resident Kupffer cells and recruited monocyte-derived macrophages with regards to regulation of liver inflammation and progression of NASH pathogenesis. Herein, we discuss recent developments concerning the function of innate immune cell subsets in NAFLD and NASH.
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Publication type
Article: Journal article
Document type
Review
Keywords
Inflammation ; Macrophages ; Neutrophils ; Non-alcoholic Fatty Liver Disease; Necrosis-factor-alpha; Induced Hepatic Steatosis; Crown-like Structures; Kupffer Cells; Neutrophil Elastase; Early-stage; Receptor 4; Cholesterol Crystals; Oxidative Stress; Stellate Cells
ISSN (print) / ISBN
1662-811X
e-ISSN
1662-8128
Journal
Journal of Innate Immunity
Quellenangaben
Pages: 1-11
Publisher
Karger
Publishing Place
Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute for Pancreatic Beta Cell Research (IPI)
Grants
Else Kroner Fresenius Center for Digital Health Dresden
German Ministry of Research and Education (BMBF)
National Institute of Dental and Craniofacial Research/National Institutes of Health (NIDCR/NIH)
German Research Foundation (DFG)
European Research Council (ERC)
German Ministry of Research and Education (BMBF)
National Institute of Dental and Craniofacial Research/National Institutes of Health (NIDCR/NIH)
German Research Foundation (DFG)
European Research Council (ERC)