PuSH - Publication Server of Helmholtz Zentrum München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Bliziotis, N.G.* ; Kluijtmans, L.A.J.* ; Soto, S.* ; Tinnevelt, G.H.* ; Langton, K.* ; Robledo, M.* ; Pamporaki, C.* ; Engelke, U.F.H.* ; Erlic, Z.* ; Engel, J.* ; Deutschbein, T.* ; Nölting, S.* ; Prejbisz, A.* ; Richter, S.* ; Prehn, C. ; Adamski, J. ; Januszewicz, A.* ; Reincke, M.* ; Fassnacht, M.* ; Eisenhofer, G.* ; Beuschlein, F.* ; Kroiss, M.* ; Wevers, R.A.* ; Jansen, J.J.* ; Deinum, J.* ; Timmers, H.J.L.M.* ; Adamski, J.*

Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma.

Endocrine, DOI: 10.1007/s12020-021-02858-z (2021)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
PURPOSE: Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors. DESIGN: A cohort of 36 PPGL patients was investigated. Blood plasma samples were collected before and after surgical tumor removal, in association with clinical and tumor characteristics. METHODS: Plasma samples were analyzed using untargeted nuclear magnetic resonance (NMR) spectroscopy metabolomics. The data were evaluated using a combination of uni- and multi-variate statistical methods. RESULTS: Before surgery, patients with a nonadrenergic tumor could be distinguished from those with an adrenergic tumor based on their metabolic profiles. Tyrosine levels were significantly higher in patients with high compared to those with low BMI. Comparing subgroups of pre-operative samples with their post-operative counterparts, we found a metabolic signature that included ketone bodies, glucose, organic acids, methanol, dimethyl sulfone and amino acids. Three signals with unclear identities were found to be affected. CONCLUSIONS: Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.
Impact Factor
Scopus SNIP
Altmetric
3.633
0.000
Tags
Annotations
Special Publikation
Hide on homepage

Edit extra information
Edit own tags
Private
Edit own annotation
Private
Hide on publication lists
on hompage
Mark as special
publikation
Publication type Article: Journal article
Document type Scientific Article
Keywords Metabolomics ; Nmr ; Operation ; Ppgl ; Paired ; Plasma; Norepinephrine; Epinephrine; Metabolism
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 1355-008X
e-ISSN 1559-0100
Journal Endocrine
Publisher Springer
Publishing Place Totowa, NJ
Reviewing status Peer reviewed
Institute(s) Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Experimental Genetics (IEG)
CF Metabolomics & Proteomics (CF-MPC)
POF-Topic(s) 30201 - Metabolic Health
30505 - New Technologies for Biomedical Discoveries
Research field(s) Genetics and Epidemiology
Enabling and Novel Technologies
PSP Element(s) G-505600-003
G-500600-001
A-630710-001
Grants ENSAT-HT - European Union
DOI 10.1007/s12020-021-02858-z
WOS ID WOS:000697088000001
Scopus ID 85115147766
PubMed ID 34536194
Erfassungsdatum 2021-10-15
[➜Report correction]