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Grahammer, F.* ; Huber, T.B.* ; Artunc, F.

Role of mTor signaling for tubular function and disease.

Physiology 36, 350-358 (2021)
Publ. Version/Full Text DOI PMC
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The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities i.e. diabetic nephropathy, AKI or hyperkalemia.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Enac ; Romk ; Endocytosis ; Mtor ; Proximal Tubule; Mammalian Target; Binding Partner; Na+ Channel; Life-span; Rapamycin; Kidney; Activation; Complex; Sgk1; Kinase
ISSN (print) / ISBN 1548-9213
e-ISSN 1548-9221
Journal Physiology
Quellenangaben Volume: 36, Issue: 6, Pages: 350-358 Article Number: , Supplement: ,
Publisher American Physiological Society
Publishing Place 6120 Executive Blvd, Suite 600, Rockville, Md, United States
Non-patent literature Publications
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants Bundesministerium fur Bildung und Forschung (BMBF)
Else Kröner-Fresenius-Stiftung (EKFS)
EC | H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC)
Deutsche Forschungsgemeinschaft (DFG)