Role of mTor signaling for tubular function and disease.
Physiology 36, 350-358 (2021)
The mechanistic target of rapamycin (mTOR) forms two distinct intracellular multiprotein complexes that control a multitude of intracellular processes linked to metabolism, proliferation, actin cytoskeleton and survival. Recent studies have identified the importance of these complexes for transport regulation of ions and nutrients along the entire nephron. First reports could link altered activity of these complexes to certain disease entities i.e. diabetic nephropathy, AKI or hyperkalemia.
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Publication type
Article: Journal article
Document type
Review
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Keywords
Enac ; Romk ; Endocytosis ; Mtor ; Proximal Tubule; Mammalian Target; Binding Partner; Na+ Channel; Life-span; Rapamycin; Kidney; Activation; Complex; Sgk1; Kinase
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Language
english
Publication Year
2021
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2021
ISSN (print) / ISBN
1548-9213
e-ISSN
1548-9221
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Volume: 36,
Issue: 6,
Pages: 350-358
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American Physiological Society
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6120 Executive Blvd, Suite 600, Rockville, Md, United States
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POF-Topic(s)
90000 - German Center for Diabetes Research
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502400-001
Grants
Bundesministerium fur Bildung und Forschung (BMBF)
Else Kröner-Fresenius-Stiftung (EKFS)
EC | H2020 | H2020 Priority Excellent Science | H2020 European Research Council (ERC)
Deutsche Forschungsgemeinschaft (DFG)
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Erfassungsdatum
2021-10-18