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Gjermeni, E.* ; Kirstein, A.S.* ; Kolbig, F.* ; Kirchhof, M.* ; Bundalian, L.* ; Katzmann, J.L.* ; Laufs, U.* ; Blüher, M. ; Garten, A.* ; Le Duc, D.

Obesity–an update on the basic pathophysiology and review of recent therapeutic advances.

Biomolecules 11:1426 (2021)
Publ. Version/Full Text DOI PMC
Open Access Gold
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Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hor-mones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat ab-sorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
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Publication type Article: Journal article
Document type Review
Keywords Anti-obesity Drugs ; Diabetes Mellitus ; Energy Balance ; Obesity ; Obesity Metabolism; Glucagon-like Peptide-1; Brown Adipose-tissue; Controlled-release Phentermine/topiramate; Gastric-inhibitory Polypeptide; Ghrelin Receptor Mutations; Type-2 Diabetes-mellitus; Diet-induced Obesity; Reduces Food-intake; Induced Weight-loss; Pancreatic-polypeptide
Language english
Publication Year 2021
HGF-reported in Year 2021
ISSN (print) / ISBN 2218-273X
e-ISSN 2218-273X
Journal Biomolecules
Quellenangaben Volume: 11, Issue: 10, Pages: , Article Number: 1426 Supplement: ,
Publisher MDPI
Publishing Place Basel
Reviewing status Peer reviewed
Institute(s) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-506501-001
Grants Project DEAL
Clinician Scientist Programm, Medizinische Fakultaet der Universitaet Leipzig
German Research Foundation
DOI 10.3390/biom11101426
WOS ID WOS:000711502600001
Scopus ID 85115918820
PubMed ID 34680059
Erfassungsdatum 2021-10-08
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