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Obesity–an update on the basic pathophysiology and review of recent therapeutic advances.
Biomolecules 11:1426 (2021)
Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hor-mones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat ab-sorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
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Publication type
Article: Journal article
Document type
Review
Keywords
Anti-obesity Drugs ; Diabetes Mellitus ; Energy Balance ; Obesity ; Obesity Metabolism; Glucagon-like Peptide-1; Brown Adipose-tissue; Controlled-release Phentermine/topiramate; Gastric-inhibitory Polypeptide; Ghrelin Receptor Mutations; Type-2 Diabetes-mellitus; Diet-induced Obesity; Reduces Food-intake; Induced Weight-loss; Pancreatic-polypeptide
ISSN (print) / ISBN
2218-273X
e-ISSN
2218-273X
Journal
Biomolecules
Quellenangaben
Volume: 11,
Issue: 10,
Article Number: 1426
Publisher
MDPI
Publishing Place
Basel
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
Project DEAL
Clinician Scientist Programm, Medizinische Fakultaet der Universitaet Leipzig
German Research Foundation
Clinician Scientist Programm, Medizinische Fakultaet der Universitaet Leipzig
German Research Foundation