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Role of ubiquilins for brown adipocyte proteostasis and thermogenesis.
Front. Endocrin. 12:739021 (2021)
The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate targeting and proteasomal degradation. However, whether ubiquilins participate in brown adipocyte function has not been investigated so far. Here, we determine the role of ubiquilins for proteostasis and non-shivering thermogenesis in brown adipocytes. We found that Ubqln1, 2 and 4 are highly expressed in BAT and their expression was induced by cold and proteasomal inhibition. Surprisingly, silencing of ubiquilin gene expression (one or multiple in combinations) did not lead to aggravated ER stress or inflammation. Moreover, ubiquitin level and proteasomal activity under basal conditions were not impacted by loss of ubiquilins. Also, non-shivering thermogenesis measured by norepinephrine-induced respiration remained intact after loss of ubiquilins. In conclusion, ubiquilin proteins are highly abundant in BAT and regulated by cold, but they are dispensable for brown adipocyte proteostasis and thermogenesis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Brown Adipose Tissue ; Cold Adaptation ; Proteostasis ; Thermogenesis ; Ubiquilins ; Ubiquitin-proteasome-system; Testis-specific Gene; Adipose-tissue
ISSN (print) / ISBN
1664-2392
e-ISSN
1664-2392
Journal
Frontiers in Endocrinology
Quellenangaben
Volume: 12,
Article Number: 739021
Publisher
Frontiers
Publishing Place
Lausanne
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
European Research Council
Deutsches Zentrum fur Herz-Kreislauf-Forschung Junior Research Group grant
Deutsche Forschungsgemeinschaft
Deutsches Zentrum fur Herz-Kreislauf-Forschung Junior Research Group grant
Deutsche Forschungsgemeinschaft