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Leptin receptor-deficient db/db mice show significant heterogeneity in response to high non-heme iron diet.
Front. Nutr. 8:741249 (2021)
Recent studies have shown an association between iron homeostasis, obesity and diabetes. In this work, we investigated the differences in the metabolic status and inflammation in liver, pancreas and visceral adipose tissue of leptin receptor-deficient db/db mice dependent on high iron concentration diet. 3-month-old male BKS-Leprdb/db/JOrlRj (db/db) mice were divided into two groups, which were fed with different diets containing high iron (29 g/kg, n = 57) or standard iron (0.178 g/kg; n = 42) concentrations for 4 months. As anticipated, standard iron-fed db/db mice developed obesity and diabetes. However, high iron-fed mice exhibited a wide heterogeneity. By dividing into two subgroups at the diabetes level, non-diabetic subgroup 1 (<13.5 mmol/l, n = 30) significantly differed from diabetic subgroup two (>13.5 mmol/l, n = 27). Blood glucose concentration, HbA1c value, inflammation markers interleukin six and tumor necrosis factor α and heme oxygenase one in visceral adipose tissue were reduced in subgroup one compared to subgroup two. In contrast, body weight, C-peptide, serum insulin and serum iron concentrations, pancreatic islet and signal ratio as well as cholesterol, LDL and HDL levels were enhanced in subgroup one. While these significant differences require further studies and explanation, our results might also explain the often-contradictory results of the metabolic studies with db/db mice.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Db/db Mice ; Diabetes Mellitus ; Inflammation ; Iron ; Metabolism ; Obesity; Improves Insulin Sensitivity; Adipose-tissue; Epithelial-cells; Genetic-analysis; Carbonyl Iron; Obesity; Glucose; Mouse; Inflammation; Adiponectin
ISSN (print) / ISBN
2296-861X
e-ISSN
2296-861X
Journal
Frontiers in Nutrition
Quellenangaben
Volume: 8,
Article Number: 741249
Publisher
Frontiers
Publishing Place
Lausanne
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
Leipzig University
Deutsche Diabetes Gesellschaft
Deutsche Diabetes Gesellschaft