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New insights into β-cell failure, regeneration and replacement.
Nat. Rev. Endocrinol. 18, 79–80 (2022)
In 2021, several discoveries shed light on the pathomechanisms of beta-cell failure during the initiation and progression of diabetes mellitus, and validated novel molecular targets for intervention. Moreover, the field of stem-cell-derived replacements for beta-cells is rapidly advancing. These advances bring us closer to therapies to protect and/or regenerate beta-cell mass.
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Publication type
Article: Journal article
Document type
Review
Keywords
Dedifferentiation; Insulin
Language
english
Publication Year
2022
Prepublished in Year
2021
HGF-reported in Year
2021
ISSN (print) / ISBN
1759-5029
e-ISSN
1759-5037
Journal
Nature Reviews - Endocrinology
Quellenangaben
Volume: 18,
Pages: 79–80
Publisher
Nature Publishing Group
Publishing Place
New York, NY
Reviewing status
Peer reviewed
POF-Topic(s)
30201 - Metabolic Health
Research field(s)
Helmholtz Diabetes Center
PSP Element(s)
G-502300-001
WOS ID
WOS:000729045500003
Scopus ID
85121363087
PubMed ID
34893788
Erfassungsdatum
2021-12-21