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Birukov, A.* ; Polemiti, E.* ; Jäger, S.* ; Stefan, N. ; Schulze, M.B.*

Fetuin-A and risk of diabetes-related vascular complications: A prospective study.

Cardiovasc. Diabetol. 21:6 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
BACKGROUND: Fetuin-A is a hepatokine which has the capacity to prevent vascular calcification. Moreover, it is linked to the induction of metabolic dysfunction, insulin resistance and associated with increased risk of diabetes. It has not been clarified whether fetuin-A associates with risk of vascular, specifically microvascular, complications in patients with diabetes. We aimed to investigate whether pre-diagnostic plasma fetuin-A is associated with risk of complications once diabetes develops. METHODS: Participants with incident type 2 diabetes and free of micro- and macrovascular disease from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam cohort (n = 587) were followed for microvascular and macrovascular complications (n = 203 and n = 60, respectively, median follow-up: 13 years). Plasma fetuin-A was measured approximately 4 years prior to diabetes diagnosis. Prospective associations between baseline fetuin-A and risk of complications were assessed with Cox regression. RESULTS: In multivariable models, fetuin-A was linearly inversely associated with incident total and microvascular complications, hazard ratio (HR, 95% CI) per standard deviation (SD) increase: 0.86 (0.74; 0.99) for total, 0.84 (0.71; 0.98) for microvascular and 0.92 (0.68; 1.24) for macrovascular complications. After additional adjustment for cardiometabolic plasma biomarkers, including triglycerides and high-density lipoprotein, the associations were slightly attenuated: 0.88 (0.75; 1.02) for total, 0.85 (0.72; 1.01) for microvascular and 0.95 (0.67; 1.34) for macrovascular complications. No interaction by sex could be observed (p > 0.10 for all endpoints). CONCLUSIONS: Our data show that lower plasma fetuin-A levels measured prior to the diagnosis of diabetes may be etiologically implicated in the development of diabetes-associated microvascular disease.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Biomarkers ; Epidemiology ; Fetuin-a ; Microvascular Complications ; Type 2 Diabetes ; Vascular Calcification ; Vascular Disease; Alpha(2)-heremans-schmid Glycoprotein/fetuin-a; Coronary-heart-disease; Fatty Liver-disease; Calciprotein Particles; Cardiovascular-disease; Insulin-resistance; Association; Calcification; Mortality; Mellitus
ISSN (print) / ISBN 1475-2840
e-ISSN 1475-2840
Journal Cardiovascular Diabetology
Quellenangaben Volume: 21, Issue: 1, Pages: , Article Number: 6 Supplement: ,
Publisher BioMed Central
Publishing Place Campus, 4 Crinan St, London N1 9xw, England
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants European Commission
Bundesministerium für Bildung und Forschung