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Ghini, V.* ; Abuja, P.M.* ; Polasek, O.* ; Kozera, L.* ; Laiho, P.* ; Anton, G. ; Zins, M.* ; Klovins, J.* ; Metspalu, A.* ; Wichmann, H.-E. ; Gieger, C. ; Luchinat, C.* ; Zatloukal, K.* ; Turano, P.*

Impact of the pre-examination phase on multicenter metabolomic studies.

New Biotech. 68, 37-47 (2022)

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The development of metabolomics in clinical applications has been limited by the lack of validation in large multicenter studies. Large population cohorts and their biobanks are a valuable resource for acquiring insights into molecular disease mechanisms. Nevertheless, most of their collections are not tailored for metabolomics and have been created without specific attention to the pre-analytical requirements for high-quality metabolome assessment. Thus, comparing samples obtained by different pre-analytical procedures remains a major challenge. Here, 1H NMR-based analyses are used to demonstrate how human serum and plasma samples collected with different operating procedures within several large European cohort studies from the Biobanking and Biomolecular Resources Infrastructure – Large Prospective Cohorts (BBMRI-LPC) consortium can be easily revealed by supervised multivariate statistical analyses at the initial stages of the process, to avoid biases in the downstream analysis. The inter-biobank differences are discussed in terms of deviations from the validated CEN/TS 16945:2016 / ISO 23118:2021 norms. It clearly emerges that biobanks must adhere to the evidence-based guidelines in order to support wider-scale application of metabolomics in biomedicine, and that NMR spectroscopy is informative in comparing the quality of different sample sources in multi cohort/center studies.

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