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Palla, G. ; Fischer, D.S. ; Regev, A.* ; Theis, F.J.

Spatial components of molecular tissue biology.

Nat. Biotechnol. 40, 308–318 (2022)
Postprint DOI PMC
Open Access Green
Methods for profiling RNA and protein expression in a spatially resolved manner are rapidly evolving, making it possible to comprehensively characterize cells and tissues in health and disease. To maximize the biological insights obtained using these techniques, it is critical to both clearly articulate the key biological questions in spatial analysis of tissues and develop the requisite computational tools to address them. Developers of analytical tools need to decide on the intrinsic molecular features of each cell that need to be considered, and how cell shape and morphological features are incorporated into the analysis. Also, optimal ways to compare different tissue samples at various length scales are still being sought. Grouping these biological problems and related computational algorithms into classes across length scales, thus characterizing common issues that need to be addressed, will facilitate further progress in spatial transcriptomics and proteomics.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Gene-expression; Resolved Transcriptomics; Analysis Strategies; Power Analysis; Cell Atlas; Seq; Identification; Microenvironment; Reconstruction; Technologies
ISSN (print) / ISBN 1087-0156
e-ISSN 1546-1696
Journal Nature Biotechnology
Quellenangaben Volume: 40, Issue: 3, Pages: 308–318 Article Number: , Supplement: ,
Publisher Nature Publishing Group
Publishing Place New York, NY
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Computational Biology (ICB)
Grants Joachim Herz Stiftung
German Research Foundation (DFG) fellowship through the Graduate School of Quantitative Biosciences Munich
sparse2big
Networking Fund through Helmholtz AI
Helmholtz Association's Initiative
BMBF
Helmholtz Association under the joint research school 'Munich School for Data Science-MUDS'