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Cooperation of RNA-binding proteins - a focus on roquin function in T cells.
Front. Immunol. 13:839762 (2022)
Post-transcriptional gene regulation by RNA-binding proteins (RBPs) is important in the prevention of inflammatory and autoimmune diseases. With respect to T cell activation and differentiation, the RBPs Roquin-1/2 and Regnase-1 play pivotal roles by inducing degradation and/or translational silencing of target mRNAs. These targets encode important proinflammatory mediators and thus Roquin and Regnase-1 functions dampen cellular programs that can lead to inflammation and autoimmune disease. Recent findings demonstrate direct physical interaction of both RBPs. Here, we propose that cooperativity of trans-acting factors may be more generally used to reinforce the regulatory impact on selected targets and promote specific cell fate decisions. We develop this concept for Roquin and Regnase-1 function in resting and activated T cells and discuss the involvement in autoimmunity as well as how the therapeutic potential can be used in anti-tumor therapies.
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Publication type
Article: Journal article
Document type
Review
Keywords
Rna-binding Proteins ; Regnase-1 ; Roquin ; Autoimmunity ; Cooperativity ; Post-transcriptional Gene Regulation ; Tumor Immunity; Constitutive-decay Element; Messenger-rna; Transcription Factor; Regnase-1; Differentiation; Nfat; Autoimmunity; Recognition; Suppresses; Activation
ISSN (print) / ISBN
1664-3224
e-ISSN
1664-3224
Journal
Frontiers in Immunology
Quellenangaben
Volume: 13,
Article Number: 839762
Publisher
Frontiers
Publishing Place
Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Abteilung für Molekulare Immunregulation (AMIR)