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Behrens, G.* ; Heissmeyer, V.

Cooperation of RNA-binding proteins - a focus on roquin function in T cells.

Front. Immunol. 13:839762 (2022)
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Post-transcriptional gene regulation by RNA-binding proteins (RBPs) is important in the prevention of inflammatory and autoimmune diseases. With respect to T cell activation and differentiation, the RBPs Roquin-1/2 and Regnase-1 play pivotal roles by inducing degradation and/or translational silencing of target mRNAs. These targets encode important proinflammatory mediators and thus Roquin and Regnase-1 functions dampen cellular programs that can lead to inflammation and autoimmune disease. Recent findings demonstrate direct physical interaction of both RBPs. Here, we propose that cooperativity of trans-acting factors may be more generally used to reinforce the regulatory impact on selected targets and promote specific cell fate decisions. We develop this concept for Roquin and Regnase-1 function in resting and activated T cells and discuss the involvement in autoimmunity as well as how the therapeutic potential can be used in anti-tumor therapies.
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Publication type Article: Journal article
Document type Review
Keywords Rna-binding Proteins ; Regnase-1 ; Roquin ; Autoimmunity ; Cooperativity ; Post-transcriptional Gene Regulation ; Tumor Immunity; Constitutive-decay Element; Messenger-rna; Transcription Factor; Regnase-1; Differentiation; Nfat; Autoimmunity; Recognition; Suppresses; Activation
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Journal Frontiers in Immunology
Quellenangaben Volume: 13, Issue: , Pages: , Article Number: 839762 Supplement: ,
Publisher Frontiers
Publishing Place Avenue Du Tribunal Federal 34, Lausanne, Ch-1015, Switzerland
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Immune Regulation (AMIR)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Immune Response and Infection
PSP Element(s) G-501712-001
DOI 10.3389/fimmu.2022.839762
WOS ID WOS:000765936800001
Scopus ID 85125854145
PubMed ID 35251035
Erfassungsdatum 2022-07-04
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