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Ni, W. ; Schneider, A.E. ; Wolf, K. ; Zhang, S. ; Chen, K.* ; Koenig, W.* ; Peters, A. ; Breitner-Busch, S.

Short-term effects of cold spells on plasma viscosity: Results from the KORA cohort study in Augsburg, Germany.

Environ. Pollut. 302:119071 (2022)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
As the underlying mechanisms of the adverse effects of cold spells on cardiac events are not well understood, we explored the effects of cold spells on plasma viscosity, a blood parameter linked to cardiovascular disease. This cross-sectional study involved 3622 participants from the KORA S1 Study (1984-1985), performed in Augsburg, Germany. Exposure data was obtained from the Bavarian State Office for the Environment. Cold spells were defined as two or more consecutive days with daily mean temperatures below the 3rd, 5th, or 10th percentile of the distribution. The effects of cold spells on plasma viscosity were explored by generalized additive models with distributed lag nonlinear models (DLNM). We estimated cumulative effects at lags 0-1, 0-6, 0-13, 0-20, and 0-27 days separately. Cold spells (mean temperature <3rd, <5th or <10th percentile) were significantly associated with an increase in plasma viscosity with a lag of 0-1 days [%change of geometric mean (95% confidence interval): 1.35 (0.06-2.68), 1.35 (0.06-2.68), and 2.49 (0.34-4.69), respectively], and a lag of 0-27 days [18.81 (8.97-29.54), 17.85 (8.29-28.25), and 7.41 (3.35-11.0), respectively]. For the analysis with mean temperature <3rd or 10th percentile, we also observed significant associations at lag 0-20 days [8.34 (0.43-16.88), and 4.96 (1.68, 8.35), respectively]. We found that cold spells had significant immediate and longer lagged effects on plasma viscosity. This finding supports the complex interplay of multiple mechanisms of cold on adverse cardiac events and enriches the knowledge about how cold exposure acts on the human body.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cold Spell ; Plasma Viscosity
ISSN (print) / ISBN 0269-7491
e-ISSN 1873-6424
Journal Environmental Pollution
Quellenangaben Volume: 302, Issue: , Pages: , Article Number: 119071 Supplement: ,
Publisher Elsevier
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)