PuSH - Publication Server of Helmholtz Zentrum München: Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.

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Chen, Y.* ; Fernandez, E.A.* ; Röger, C.* ; Lopez-Mejia, I.C.* ; Fajas Coll, L.* ; Ji, H.

Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.

FEBS Lett. 596, 1434-1444 (2022)

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Adipose tissue regulates whole-body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin-dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue-specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and down-regulation of fat-specific genes, which are aggravated on high-fat diet and during aging. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.

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