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Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.
FEBS Lett. 596, 1434-1444 (2022)
Publ. Version/Full Text
Research data
DOI
PMC
Adipose tissue regulates whole-body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin-dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue-specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and down-regulation of fat-specific genes, which are aggravated on high-fat diet and during aging. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Adipose Tissue ; Cyclin-dependent Kinase 7 ; Lipid Metabolism ; Lipodystrophy
ISSN (print) / ISBN
0014-5793
e-ISSN
1873-3468
Journal
FEBS Letters
Quellenangaben
Volume: 596,
Issue: 11,
Pages: 1434-1444
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung