PuSH - Publication Server of Helmholtz Zentrum München: Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels.

Navigation

Home

Deutsch

Research

Advanced Search

Browse by ...

... Journal

... Publication Type

... Research Data

... Publication Year

Publication overview

Support & Contact

Contact persons

Help

Data protection

Qi, R.* ; Cao, J.* ; Sun, Y.* ; Li, Y.* ; Huang, Z.* ; Jiang, D. ; Jiang, X.H.* ; Snutch, T.P.* ; Zhang, Y.* ; Tao, J.*

Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels.

Proc. Natl. Acad. Sci. U.S.A. 119:e2117209119 (2022)

Publ. Version/Full Text

Research data

DOI

PMC

	Open Access Gold (Paid Option)

Abstract
Metrics
Extra information

SignificanceIn this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to the promoter region of the miR-32-5p gene and decreases the expression of miR-32-5p, in turn promoting the development of neuropathic pain through regulation of Cav3.2 channels. miRNA-mediated gene regulation has been proposed as a therapeutic approach in neuropathic pain. Our findings identify miR-32-5p replenishment as a therapeutic strategy for treating chronic neuropathic pain.

Altmetric

Additional Metrics?

[➜Log in]

Edit extra informations Login

Publication type Article: Journal article

Document type Scientific Article

Corresponding Author

Keywords Cav3.2 ; Microrna ; Neuropathic Pain ; T-type Ca2+ Channels ; Trigeminal Ganglion Neurons

ISSN (print) / ISBN 0027-8424

e-ISSN 1091-6490

Journal Proceedings of the National Academy of Sciences of the United States of America

Quellenangaben Volume: 119, Issue: 14, Article Number: e2117209119

Publisher National Academy of Sciences

Non-patent literature Publications

Reviewing status Peer reviewed

Institute(s) Institute of Regenerative Biology and Medicine (IRBM)

Grants Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation)
Research Innovation Program for College Graduates of Jiangsu Province
Science and Technology Bureau of Suzhou
Jiangsu Key Laboratory of Neuropsychiatric Diseases
Priority Academic Program Development of Jiangsu Higher Education Institutions
National Natural Science Foundation of China (NSFC)