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Qi, R.* ; Cao, J.* ; Sun, Y.* ; Li, Y.* ; Huang, Z.* ; Jiang, D. ; Jiang, X.H.* ; Snutch, T.P.* ; Zhang, Y.* ; Tao, J.*

Histone methylation-mediated microRNA-32-5p down-regulation in sensory neurons regulates pain behaviors via targeting Cav3.2 channels.

Proc. Natl. Acad. Sci. U.S.A. 119:e2117209119 (2022)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
SignificanceIn this study, we identify microRNA-32-5p (miR-32-5p) as a key functional noncoding RNA in trigeminal-mediated neuropathic pain. We report that injury-induced histone methylation attenuates the binding of glucocorticoid receptor to the promoter region of the miR-32-5p gene and decreases the expression of miR-32-5p, in turn promoting the development of neuropathic pain through regulation of Cav3.2 channels. miRNA-mediated gene regulation has been proposed as a therapeutic approach in neuropathic pain. Our findings identify miR-32-5p replenishment as a therapeutic strategy for treating chronic neuropathic pain.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cav3.2 ; Microrna ; Neuropathic Pain ; T-type Ca2+ Channels ; Trigeminal Ganglion Neurons
Language english
Publication Year 2022
HGF-reported in Year 2022
ISSN (print) / ISBN 0027-8424
e-ISSN 1091-6490
Journal Proceedings of the National Academy of Sciences of the United States of America
Quellenangaben Volume: 119, Issue: 14, Pages: , Article Number: e2117209119 Supplement: ,
Publisher National Academy of Sciences
Reviewing status Peer reviewed
Institute(s) Institute of Regenerative Biology and Medicine (IRBM)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-509400-001
Grants Natural Science Foundation of Jiangsu Province (Jiangsu Natural Science Foundation)
Research Innovation Program for College Graduates of Jiangsu Province
Science and Technology Bureau of Suzhou
Jiangsu Key Laboratory of Neuropsychiatric Diseases
Priority Academic Program Development of Jiangsu Higher Education Institutions
National Natural Science Foundation of China (NSFC)
DOI 10.1073/pnas.2117209119
WOS ID WOS:000819656000009
Scopus ID 85127229610
PubMed ID 35353623
Erfassungsdatum 2022-05-03
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