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Theoretical and experimental studies of phosphonium ionic liquids as potential antibacterials of MDR Acinetobacter baumannii.
Antibiotics 11:491 (2022)
A previously developed model to predict antibacterial activity of ionic liquids against a resistant A. baumannii strain was used to assess activity of phosphonium ionic liquids. Their antioxidant potential was additionally evaluated with newly developed models, which were based on public data. The accuracy of the models was rigorously evaluated using cross-validation as well as test set prediction. Six alkyl triphenylphosphonium and alkyl tributylphosphonium bromides with the C8, C10, and C12 alkyl chain length were synthesized and tested in vitro. Experimental studies confirmed their activity against A. baumannii as well as showed pronounced antioxidant properties. These results suggest that phosphonium ionic liquids could be promising lead structures against A. baumannii.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Acinetobacter Baumannii ; Antibacterial ; Antioxidants ; Ochem ; Phosphonium Ionic Liquids ; Qsar
ISSN (print) / ISBN
2079-6382
e-ISSN
2079-6382
Journal
Antibiotics
Quellenangaben
Volume: 11,
Issue: 4,
Article Number: 491
Publisher
MDPI
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Structural Biology (STB)
Grants
Federal Ministry of Education & Research (BMBF)